Actively Recruiting
Mapping Breast and Prostate Cancer through Genomic Sequencing in the Brazilian Public Health System
Led by Hospital Moinhos de Vento · Updated on 2026-02-13
882
Participants Needed
25
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research aims to map breast and prostate cancer in patients treated through the Brazilian Unified Health System by performing complete sequencing of tumor somatic and germline exomes. It focuses on understanding molecular variants in tumors, which can affect treatment response and disease prognosis. The project also seeks to identify hereditary genetic syndromes and collect data on the populations ancestry for the Brazilian Ministry of Healths National Precision Genomics and Health Program, Genomas Brasil. The study includes two groups 745 patients with HER2-positive and triple-negative breast cancer who underwent neoadjuvant therapy followed by surgery, and 137 patients with metastatic prostate cancer. Sequencing involves somatic and germline whole exome analysis for prostate and HER2-positive breast cancer, and somatic whole exome with germline whole genome sequencing for triple-negative breast cancer. Participants will provide tumor tissue and blood samples for genomic analysis. Researchers will characterize complete somatic and germline exomesgenomes within 12 months, identify genetic variants related to tumor prognosis and treatment response, and count patients with mutations in cancer-predisposing genes. The study runs until 2026 and data will support precision oncology efforts in Brazil.
CONDITIONS
Brief Title
Onco-Genomas Brasil: Mapping Breast and Prostate Cancer in the Brazilian Public Health System
Research Team
M
Marina Bessel
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