Actively Recruiting
Oncological Safety of Spleen Preservation in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID)
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2025-09-05
94
Participants Needed
10
Research Sites
317 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to determine how often lymph node metastases occur in the splenic hilum and surrounding fat in patients with left-sided pancreatic cancer. The main question the study aims to answer is: Is spleen removal necessary in all cases, or is the risk of lymph node metastases in the fat around the spleen low enough to reconsider this standard practice? Currently, spleen removal is part of the standard treatment for patients with left-sided pancreatic cancer to ensure that any potential lymph node metastases in the surrounding fat are also removed. However, the likelihood of metastases in this area is low, and spleen removal carries risks. This study is a first step toward changing the treatment approach. If the findings show that metastases in the fat around the spleen are rare, the next step will be a randomized trial to further investigate whether spleen removal is necessary.
CONDITIONS
Official Title
Oncological Safety of Spleen Preservation in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Undergoing open or minimally invasive left-sided pancreatectomy with spleen removal
- Diagnosed with primary resectable, borderline resectable, or locally advanced left-sided pancreatic ductal adenocarcinoma
You will not qualify if you...
- Tumor involvement or abutment of the spleen
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
BenQ Hospital
Nanjing, China
Actively Recruiting
2
Konstantopoulio General Hospital
Athens, Greece
Actively Recruiting
3
Padova University Hospital
Padova, Italy
Actively Recruiting
4
Kyushu University Hospital
Fukuoka, Japan
Actively Recruiting
5
Amsterdam UMC
Amsterdam, Netherlands
Actively Recruiting
6
OLVG Hospital
Amsterdam, Netherlands
Actively Recruiting
7
Leiden University Medical Center
Leiden, Netherlands
Actively Recruiting
8
Oslo University Hospital
Oslo, Norway
Actively Recruiting
9
Dr. Peset University Hospital
Valencia, Spain
Actively Recruiting
10
Linköping University Hospital
Linköping, Sweden
Actively Recruiting
Research Team
J
Jony van Hilst, MD, PhD
CONTACT
C
Caro L Bruna, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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