Actively Recruiting
One-Month DAPT in CABG Patients
Led by Weill Medical College of Cornell University · Updated on 2025-12-22
700
Participants Needed
22
Research Sites
332 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to compare the effect of ticagrelor plus low-dose aspirin versus low-dose aspirin alone in patients with chronic coronary disease undergoing coronary artery bypass grafting.
CONDITIONS
Official Title
One-Month DAPT in CABG Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Scheduled for elective first-time coronary artery bypass grafting using at least one saphenous vein graft
- Able to provide informed consent and comply with study procedures, including follow-up for at least 5 years
You will not qualify if you...
- Need for dual antiplatelet therapy due to acute or recent acute coronary syndrome within 1 year or recent PCI requiring ongoing dual therapy after CABG
- Current or planned use of oral anticoagulants
- Presence of any type of atrial fibrillation (paroxysmal, persistent, or permanent)
- Undergoing any other cardiac or non-cardiac surgery or procedure
- Planned surgery within one year
- Severe preoperative organ dysfunction (dialysis, moderate to severe liver failure, respiratory failure), cancer, or other conditions limiting life expectancy to less than 5 years
- Inability to use saphenous vein graft
- Contraindications to aspirin
- Contraindications to ticagrelor, including known allergy, active bleeding, history of brain hemorrhage, or use of strong CYP3A4 inhibitors
- Unable to have coronary computed tomographic angiography
- Participation in another investigational study
- Women of childbearing potential
- Major complications during surgery such as stroke, TIA, myocardial infarction, bleeding related to CABG, or sepsis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
Englewood Hospital
Englewood, New Jersey, United States, 07631
Actively Recruiting
2
NewYork-Presbyterian: Queens Hospital
Flushing, New York, United States, 11355
Actively Recruiting
3
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
4
Medical University Innsbruck
Innsbruck, Innsbruck, Austria, 6020
Actively Recruiting
5
Medical University Graz
Graz, Austria
Actively Recruiting
6
Johannes Kepler University Linz
Linz, Austria
Actively Recruiting
7
Medical University of Vienna
Vienna, Austria, 1090
Actively Recruiting
8
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Not Yet Recruiting
9
Ruijin Hospital: Shanghai Jiao Tong University School of Medicine
Shanghai, China, China, 200023
Actively Recruiting
10
Jilin Heart Hospital
Changchun, Jilian, China
Actively Recruiting
11
Beijing Anzhen Hospital
Beijing, China, 100029
Actively Recruiting
12
Center China Fuwai Hospital
Beijing, China
Actively Recruiting
13
University Hospital of Düsseldorf
Düsseldorf, Germany
Actively Recruiting
14
Westdeutsches Herz- und Gefäßzentrum Essen, Universität Duisburg-Essen
Essen, Germany
Not Yet Recruiting
15
Klinik für Herz- und Gefäßchirurgie - Universitäts-Herzzentrum Freiburg - Bad Krozingen
Freiburg im Breisgau, Germany
Actively Recruiting
16
University Hospital Giessen
Giessen, Germany, 35043
Actively Recruiting
17
Jena University Hospital
Jena, Germany
Actively Recruiting
18
LMU Klinikum Campus Großhadern
München, Germany
Not Yet Recruiting
19
Robert-Bosch-Krankenhaus Stuttgart
Stuttgart, Germany
Not Yet Recruiting
20
Sahlgrenska University Hospital
Gothenburg, Sweden, 413 45
Actively Recruiting
21
Sahlgrenska University Hospital Sweden
Gothenburg, Sweden
Not Yet Recruiting
22
Skåne University Hospital
Malmö, Sweden, 214 28
Actively Recruiting
Research Team
T
Trisha Ali-Shaw
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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