Actively Recruiting
One-stage Exchange in Candida Periprosthetic Infection a Suitable Way to go
Led by University Hospital, Strasbourg, France · Updated on 2025-12-24
16
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying Candida yeast infections in joint prostheses, which are rare but challenging to treat. The study focuses on comparing single-stage versus two-stage prosthesis replacement for chronic Candida infections, aiming to determine if one-stage replacement combined with antifungal treatment can achieve similar success rates. Past studies have been limited and retrospective, with varied success rates. This observational study is sponsored by the University Hospital, Strasbourg, France. The study observes patients who had hip or knee prosthesis revisions with possible or confirmed Candida infections. It reviews treatment outcomes without assigning interventions, focusing on cases treated with systemic antifungal therapy. Participants include those operated on at Strasbourg University Hospitals between 2013 and 2021. The main period of observation covers up to one year after hospital stay to assess infection eradication. Participants' medical records will be reviewed for infection outcomes using diagnostic criteria and sample analyses. The main measure is the eradication rate of Candida infections during hospital stay and up to one year. The study monitors antifungal treatment use and prosthesis replacement type. Participants are followed through their clinical course to understand infection control and treatment success over time.
CONDITIONS
Brief Title
One-stage Exchange in Candida Periprosthetic Infection a Suitable Way to go
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged over 18 years at the time of prosthesis revision
- Operated on at the Strasbourg University Hospitals between January 1, 2013, and December 31, 2021
- Hip or knee prosthesis revision
- Possible or proven periprosthetic Candida spp. infection according to the EBJIS diagnostic criteria
- At least 3 deep samples taken (joint fluid, preoperative sample, and/or prosthesis sonication)
You will not qualify if you...
- Patient undergoing lavage, synovectomy, and implant preservation
- Patient not receiving systemic antifungal treatment after prosthesis replacement
- Patient with another proven Candida spp. infection or infective endocarditis
- Patient prescribed suppressive therapy before surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants who undergo routine care for Candida periprosthetic infection are observed to assess infection eradication during their hospital stay and up to 1 year.
Follow-up visits as part of routine healthcare
Trial Site Locations
Total: 1 location
1
Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
S
Stéphane Klein, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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