Actively Recruiting
One-Time DNA Study for Vasculitis
Led by University of Pennsylvania · Updated on 2026-01-22
1000
Participants Needed
14
Research Sites
930 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.
CONDITIONS
Official Title
One-Time DNA Study for Vasculitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Giant Cell Arteritis with disease onset after age 50 and meeting at least one of the specified clinical or biopsy criteria
- Diagnosis of Takayasu's Arteritis with disease onset before age 50 and meeting at least one of the listed clinical or angiographic criteria
- Diagnosis of Polyarteritis Nodosa with major or minor criteria attributable to vasculitis or biopsy-proven cutaneous PAN
- Diagnosis of Granulomatosis with Polyangiitis or Microscopic Polyangiitis meeting accepted diagnostic criteria including clinical signs, biopsy, or antibody tests
- Diagnosis of Eosinophilic Granulomatosis with Polyangiitis meeting at least four of six clinical criteria or documented small vessel vasculitis
- Participants aged 7 years or older
You will not qualify if you...
- Unable to give informed consent or unwilling to sign the consent form
- Currently enrolled in VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
- Unwilling to provide blood for DNA collection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Completed
2
University of California, San Francisco
San Francisco, California, United States, 94143
Completed
3
Northwestern University
Chicago, Illinois, United States, 60208
Actively Recruiting
4
University of Kansas Medical Center
Kansas City, Kansas, United States, 66103
Completed
5
University of Michigan
Ann Arbor, Michigan, United States, 48109-5422
Completed
6
Mayo Clinic
Rochester, Minnesota, United States, 55905
Completed
7
Hospital for Special Surgery
New York, New York, United States, 10021
Completed
8
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Completed
9
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
10
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15261
Completed
11
University of Utah
Salt Lake City, Utah, United States, 84132
Completed
12
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Actively Recruiting
13
Mount Sinai Hospital
Toronto, Ontario, Canada, M5T 3L9
Actively Recruiting
14
Istanbul University
Istanbul, Fatih, Turkey (Türkiye), 34452
Completed
Research Team
C
Carol McAlear, MA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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