Self-Reported Data and Physician-Reported Data in Patients With Eosinophilic Granulomatosis With Polyangiitis: Comparative Analysis.
Irena Doubelt, Jason M Springer, Tanaz A Kermani...
https://pubmed.ncbi.nlm.nih.gov/35612893Actively Recruiting
Age: 7Years +
All Genders
ID01241305
VCRC Genetic Repository One-Time DNA Protocol for Vasculitis Research
Led by University of Pennsylvania · Updated on 2026-01-22
1000
Participants Needed
14
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the genetic factors that may increase the risk of developing vasculitis, a group of serious diseases involving inflammation of blood vessels. This study focuses on six specific types of vasculitis, chosen to represent a range of vessel sizes and unmet medical needs. The goal is to better understand the causes of these rare diseases and generate new ideas for diagnostic tests and treatments. The study involves a one-time collection of clinical data and DNA samples from participants with one of the six vasculitis types. This approach helps include patients who cannot frequently visit study centers, especially those with rarer forms of vasculitis or elderly patients. There are no drug treatments or interventions involved, as this is an observational genetic research study. Participants provide information and a DNA sample during a single visit. Researchers will evaluate this clinical data and linked DNA specimens over one year to identify genetic associations with vasculitis. Throughout the study, no additional treatments or follow-up visits are required. The total participation time is limited to this one-time collection and subsequent analysis period.
CONDITIONS
Brief Title
One-Time DNA Study for Vasculitis
Who Can Participate
Age: 7Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosed with Giant Cell Arteritis with disease onset over 50 years old, meeting specific clinical signs or biopsy results
- Diagnosed with Takayasu's Arteritis with disease onset under 50 years old, meeting specific vascular symptoms and imaging criteria
- Diagnosed with Polyarteritis Nodosa with major or minor criteria related to vasculitis, or biopsy-proven cutaneous PAN
- Diagnosed with Granulomatosis with Polyangiitis or Microscopic Polyangiitis meeting established clinical and laboratory criteria
- Diagnosed with Eosinophilic Granulomatosis with Polyangiitis meeting at least 4 of 6 specific clinical criteria
- Able to provide informed consent and sign the consent form
- Willing to provide blood for DNA collection
- At least 7 years old
You will not qualify if you...
- Unable to give informed consent or sign the consent form
- Currently enrolled in specific VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
- Unwilling to provide blood for DNA collection or participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - One-time
Participants provide clinical data and blood samples for DNA collection to support genetic research on vasculitis.
1 visit (in-person)
Long-term Monitoring
Duration - 1 year
Participants' clinical data and DNA specimens are evaluated over one year to support genetic association studies.
No additional visits required
Trial Site Locations
Total: 14 locations
1
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Completed
2
University of California, San Francisco
San Francisco, California, United States, 94143
Completed
3
Northwestern University
Chicago, Illinois, United States, 60208
Actively Recruiting
4
University of Kansas Medical Center
Kansas City, Kansas, United States, 66103
Completed
5
University of Michigan
Ann Arbor, Michigan, United States, 48109-5422
Completed
6
Mayo Clinic
Rochester, Minnesota, United States, 55905
Completed
7
Hospital for Special Surgery
New York, New York, United States, 10021
Completed
8
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Completed
9
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
10
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15261
Completed
11
University of Utah
Salt Lake City, Utah, United States, 84132
Completed
12
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Actively Recruiting
13
Mount Sinai Hospital
Toronto, Ontario, Canada, M5T 3L9
Actively Recruiting
14
Istanbul University
Istanbul, Fatih, Turkey (Türkiye), 34452
Completed
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Research Team
C
Carol McAlear, MA
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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