Actively Recruiting
ONO-4538 Study in Patients With Richter's Transformation
Led by Ono Pharmaceutical Co., Ltd. · Updated on 2026-02-13
14
Participants Needed
10
Research Sites
245 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Investigate the efficacy and safety of ONO-4538 in patients with Richter's transformation
CONDITIONS
Official Title
ONO-4538 Study in Patients With Richter's Transformation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological diagnosis of diffuse large B-cell lymphoma (DLBCL)-type or Hodgkin lymphoma(HL)-type Richter's transformation with a history of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
- In the case of DLBCL-type Richter's transformation, refractory, intolerant or ineligible for treatment of DLBCL
- Patients with measurable disease
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Expected to survive for 90 days or more
You will not qualify if you...
- Serious complications
- Active multiple cancers
- Active central nervous system (CNS) disease
- History of allogeneic hematopoietic stem cell transplantation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Aichi Cancer Center
Nagoya, Aichi-ken, Japan
Actively Recruiting
2
Kyusyu University Hospital
Fukuoka, Fukuoka, Japan, 812-8582
Actively Recruiting
3
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Hiroshima, Hiroshima, Japan
Actively Recruiting
4
Hokkaido University Hospital
Sapporo, Hokkaido, Japan, 060-8648
Actively Recruiting
5
Kyoto University Hospital
Kyoto, Kyoto, Japan
Actively Recruiting
6
Tohoku University Hospital
Sendai, Miyagi, Japan
Actively Recruiting
7
Niigata University Medical & Dental Hospital
Niigata, Niigata, Japan
Actively Recruiting
8
Kindai University Hospital
Ōsaka-sayama, Osaka, Japan
Actively Recruiting
9
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Bunkyō-Ku, Tokyo, Japan
Actively Recruiting
10
National Cancer Center Hospital
Chuo Ku, Tokyo, Japan
Actively Recruiting
Research Team
N
North America Clinical Trial Support Desk
CONTACT
I
International Clinical Trial Support Desk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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