Actively Recruiting
An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)
Led by Annexon, Inc. · Updated on 2026-02-20
30
Participants Needed
9
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this open label study is to measure pharmacokinetics, pharmacodynamics, early efficacy, and safety of tanruprubart in adult and pediatric participants, in the United States, Canada, and Europe.
CONDITIONS
Official Title
An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Guillain-Barre Syndrome according to the National Institute of Neurological Disorders and Stroke criteria
- Onset of GBS-related weakness 10 days or less before the first dose
- GBS disability score of 3, 4, or 5 at screening and before infusion start
You will not qualify if you...
- Previous or intended treatment with plasma exchange or IV immunoglobulin for GBS
- Diagnosis of a GBS variant such as Miller Fisher syndrome, Bickerstaff's encephalitis, or overlap syndromes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
HonorHealth Bob Bové Neuroscience Institute
Scottsdale, Arizona, United States, 85251
Actively Recruiting
2
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
3
University of California Irvine
Orange, California, United States, 92868
Actively Recruiting
4
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
5
Ochsner LSU Health
Shreveport, Louisiana, United States, 71101
Actively Recruiting
6
University Massachusetts Chan Medical School
Worcester, Massachusetts, United States, 01655
Actively Recruiting
7
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
8
Mayo Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
9
Aarhus University Hospital
Aarhus, Aarhus N, Denmark, 8200
Actively Recruiting
Research Team
S
Study Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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