Actively Recruiting
An Open-Label Extension Study of ORKA-001 in Participants With Plaque Psoriasis
Led by Oruka Therapeutics, Inc. · Updated on 2026-04-22
80
Participants Needed
17
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
An open-label extension (OLE) study to evaluate the long-term safety and efficacy of ORKA-001 in adult participants with moderate-to-severe plaque psoriasis, who previously participated in an Oruka Therapeutics sponsored study.
CONDITIONS
Official Title
An Open-Label Extension Study of ORKA-001 in Participants With Plaque Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent from participants who completed the previous trial and chose to enter this extension study
- Successfully completed the preceding trial
- Women of childbearing potential must have a negative urine pregnancy test at baseline
- Women of childbearing potential and fertile male participants with partners of childbearing potential must agree to use highly effective contraception
You will not qualify if you...
- Experienced adverse events with ORKA-001 in the previous trial that prevent continued treatment
- Developed guttate, erythrodermic, pustular, or drug-induced psoriasis during the previous trial
- Have any significant disease or medical condition other than psoriasis that could affect safety or data quality
- Have clinically significant lab abnormalities from the previous trial that prevent continued treatment
- Are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Oruka Therapeutics Investigative Site
Los Angeles, California, United States, 90045
Actively Recruiting
2
Oruka Therapeutics Investigative Site
San Diego, California, United States, 92123
Actively Recruiting
3
Oruka Therapeutics Investigative Site
Santa Ana, California, United States, 92701
Actively Recruiting
4
Oruka Therapeutics Investigative Site
Santa Monica, California, United States, 90404
Actively Recruiting
5
Oruka Therapeutics Investigative Site
Cromwell, Connecticut, United States, 06416
Actively Recruiting
6
Oruka Therapeutics Investigative Site
Coral Gables, Florida, United States, 33134
Actively Recruiting
7
Oruka Therapeutics Investigative Site
Bowling Green, Kentucky, United States, 42104
Actively Recruiting
8
Oruka Therapeutics Investigative Site
Rockville, Maryland, United States, 20850
Actively Recruiting
9
Oruka Therapeutics Investigative Site
Detroit, Michigan, United States, 48202
Actively Recruiting
10
Oruka Therapeutics Investigative Site
New York, New York, United States, 10023
Actively Recruiting
11
Oruka Therapeutics Investigative Site
New York, New York, United States, 10029
Actively Recruiting
12
Oruka Therapeutics Investigative Site
Portland, Oregon, United States, 97201
Actively Recruiting
13
Oruka Therapeutics Investigative Site
Surrey, British Columbia, Canada, V3R 6A7
Actively Recruiting
14
Oruka Therapeutics Investigative Site
London, Ontario, Canada, N6H 5L5
Actively Recruiting
15
Oruka Therapeutics Investigative Site
Markham, Ontario, Canada, L3P 1X3
Actively Recruiting
16
Oruka Therapeutics Investigative Site
Peterborough, Ontario, Canada, K9J 5K2
Actively Recruiting
17
Oruka Therapeutics Investigative Site
Toronto, Ontario, Canada, M4W 2N4
Actively Recruiting
Research Team
O
Oruka Clinical Trials Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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