Actively Recruiting
An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Led by Zomagen Biosciences Ltd. · Updated on 2026-05-05
50
Participants Needed
17
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a study to understand if taking VTX2735 is safe and effective in participants diagnosed with Recurrent Pericarditis (RP). Cohort A will include approximately 10 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose A * A 7-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose A * An 11-week Once Daily Treatment Period (if a participant meets criteria for this treatment period) - participant receives VTX2735 Dose B * A 14-day Follow-Up Period Cohort B will include approximately 20 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose B or C * An 18-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose B or C * A 14-day Follow-Up Period Cohort C will include approximately 20 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose D or E, and B * An 18-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose B * A 14-day Follow-Up Period
CONDITIONS
Official Title
An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 to 75 years
- Able to give signed informed consent and comply with the study protocol
- Have had a first episode of pericarditis meeting acute criteria
- Have ongoing symptoms of pericarditis or expect an episode within 4 weeks
- CRP blood test before first dose; if CRP is 10 mg/L or lower, must be on corticosteroids with evidence of pericardial inflammation
- Pericarditis pain score of 4 or higher on an 11-point scale
- Stable doses of NSAIDs, colchicine, and/or oral corticosteroids if these treatments are used
You will not qualify if you...
- Current or past pericarditis caused by tuberculosis, blunt trauma, tumor, myocarditis, or systemic autoimmune diseases
- History of serious immunosuppressive disorders, autoimmune or autoinflammatory diseases, or immunodeficiency
- Any significant medical condition that could affect safety or study data quality as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Local Site #840012
Tucson, Arizona, United States, 85718
Withdrawn
2
Local Site #840014
Orange, California, United States, 92868
Actively Recruiting
3
Local Site #840016
Saint Augustine, Florida, United States, 32086
Actively Recruiting
4
Local Site #840008
Chicago, Illinois, United States, 60611
Actively Recruiting
5
Local Site #840002
Park Ridge, Illinois, United States, 60068
Withdrawn
6
Local Site #840011
Owensboro, Kentucky, United States, 42303
Withdrawn
7
Local Site #840010
Boston, Massachusetts, United States, 02114
Actively Recruiting
8
Local Site #840005
Rochester, Minnesota, United States, 55905
Actively Recruiting
9
Local Site #840020
New York, New York, United States, 10032
Actively Recruiting
10
Local Site #840017
Cleveland, Ohio, United States, 44195
Actively Recruiting
11
Local Site #840019
Houston, Texas, United States, 77030
Actively Recruiting
12
Local Site #840001
Houston, Texas, United States, 77034
Actively Recruiting
13
Local Site #840013
Salt Lake City, Utah, United States, 84132
Actively Recruiting
14
Local Site #840018
Charlottesville, Virginia, United States, 22908
Actively Recruiting
15
Local Site #840004
Richmond, Virginia, United States, 23219
Actively Recruiting
16
Local Site #840021
Seattle, Washington, United States, 98105
Actively Recruiting
17
Local Site #840101
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
Research Team
V
Ventyx Clinical Trial Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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