Actively Recruiting
Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital
Led by Mansoura University Children Hospital · Updated on 2025-10-01
110
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our study is a randomized controlled trial that compares two weaning protocols of preterm infants with respiratory distress syndrome who are ventilated on high frequency oscillatory ventilation in order to establish the best weaning strategy with the least complications possible for this group of patients.
CONDITIONS
Official Title
Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preterm infants with respiratory distress syndrome born at 34 weeks gestation or less
- Required high frequency oscillatory ventilation for more than 24 hours due to failure of non-invasive respiratory support caused by any of the following: severe hypercapnea (PaCO2 > 60 mmHg with pH < 7.25), hypoxemia (PaO2 < 50 mmHg with FiO2 > 40%), or frequent apneas (6 or more episodes within 6 hours or one apneic episode requiring positive pressure ventilation)
You will not qualify if you...
- Major congenital malformations or chromosomal abnormalities
- Inborn errors of metabolism
- Severe intraventricular hemorrhage grade III or IV
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mansoura University Children Hospital
Al Mansurah, Egypt
Actively Recruiting
Research Team
Y
Yasmina E Keshta
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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