Randomized Trial Comparing Two Weaning Methods from High Frequency Oscillatory Ventilation in Preterm Babies with Respiratory Distress Syndrome

What this Trial Is About

This research aims to compare two different protocols for weaning preterm infants with respiratory distress syndrome RDS who are on high frequency oscillatory ventilation HFOV. The goal is to find the best weaning strategy that results in the fewest complications for these vulnerable newborns. The study is a randomized controlled trial conducted at Mansoura University Children Hospital and focuses on infants born at 34 weeks gestation or earlier. Participants are randomly assigned to one of two groups. The first group is weaned directly from HFOV to continuous positive airway pressure CPAP. The second group is weaned from HFOV to conventional mechanical ventilation CMV before moving to CPAP. Each group includes 55 preterm infants, and the trial compares the outcomes of these two weaning methods. During the study, researchers monitor the infants closely to measure the rate of weaning failure within 72 hours after weaning. This involves observing respiratory status and any complications during this critical period. The study does not use blinding. The total participation duration and additional assessments are not specified, but the primary focus is on the immediate success of the weaning protocols.

Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital