Actively Recruiting
An Open-label Study of Cizutamig in Refractory Seropositive Rheumatoid Arthritis
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2026-01-12
28
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the safety and efficacy of BCMAxCD3 T-cell engager (cizutamig) in patients with refractory seropositive RA.
CONDITIONS
Official Title
An Open-label Study of Cizutamig in Refractory Seropositive Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years at time of informed consent
- Diagnosis of adult-onset rheumatoid arthritis by 2010 ACR/EULAR criteria
- Moderately to severely active rheumatoid arthritis
- Positive rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) at screening
- Inadequate treatment response or intolerance to tsDMARD and/or bDMARD therapies
You will not qualify if you...
- Abnormal clinical laboratory results at screening
- Active infection
- Received live vaccine within 4 weeks before screening
- Presence of any other autoimmune disease
- History of progressive multifocal leukoencephalopathy
- History of primary immunodeficiency or hereditary complement deficiency
- Central nervous system disease
- Significant other medical conditions judged by investigator
- Diagnosis or history of cancer within 5 years
- Serious mental illness, alcohol or drug abuse, dementia, or conditions impairing ability to consent or follow treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wuhan Union Hospital
Wuhan, Hubei, China, 430000
Actively Recruiting
Research Team
Q
Qiubai Li, Professor
CONTACT
D
Di Wu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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