Study of Repetitive Transcranial Magnetic Stimulation Targeting the Supplementary Motor Area to Improve Motor Symptoms in Parkinsons Disease

What this Trial Is About

Researchers are evaluating the use of repetitive transcranial magnetic stimulation rTMS, a non-invasive brain stimulation technique, to improve motor symptoms in patients with Parkinsons disease. This study focuses on targeting the supplementary motor area SMA, a brain region linked to motor function, using precise neuroimaging navigation. The goal is to assess the clinical effects of this targeted rTMS intervention in patients with idiopathic Parkinsons disease. Participants will be randomly assigned to receive either real or sham stimulation. The treatment involves continuous theta burst stimulation cTBS applied to the left SMA for 7 consecutive days. Each day includes six cTBS sessions, separated by 15-minute intervals, with each session lasting 40 seconds and delivering a total of 600 pulses at 80% of the resting motor threshold. The intervention is given alongside participants usual drug treatments. During the study, participants will be evaluated using the Movement Disorder Society-Sponsored Revision of the Unified Parkinsons Disease Rating Scale MDS-UPDRS Part III to measure motor symptom changes at baseline, day 8, week 5, and week 9. Additional assessments include the Hoehn-Yahr staging and the timed up and go test at the same time points. Safety and symptom monitoring will continue throughout the study, which is expected to last until March 2025.

An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD