Actively Recruiting
Open Pilon With FIBERGRAFT AERIDYAN Matrix Bioactive Glass
Led by University of Missouri-Columbia · Updated on 2025-11-12
45
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
Sponsors
U
University of Missouri-Columbia
Lead Sponsor
D
DePuy Orthopaedics
Collaborating Sponsor
AI-Summary
What this Trial Is About
Open pilon fractures are challenging problems to manage. Infection rates vary from 6-30% and metaphyseal nonunion varies from 7-20%. The current recommendation for the management of open pilon fractures with bone loss is a staged approach, with internal fixation around an antibiotic spacer. Fibergraft Aeridyan Bone Graft Matrix is currently used along with other forms of allograft at our institution for filling bone voids in open pilon fractures. This is a prospective, observational study looking at the use of Fibergraft Aeridyan bone graft matrix and its efficacy in open pilon fractures. Everything in this study will be according to the standard of care at our institution other than two research only CT scans. One will be performed at the patient's 6-month visit and the other will be performed at the patient's 12-month visit. The investigators hypothesize that Fibergraft Aeridyan Bone Graft Matrix will lead to improved outcomes when compared to standard bone graft for patients by decreasing infection and nonunion rates.
CONDITIONS
Official Title
Open Pilon With FIBERGRAFT AERIDYAN Matrix Bioactive Glass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Open pilon fracture requiring bone grafting
- Able to provide informed consent for the study prior to definitive care
You will not qualify if you...
- Under 18 years of age
- Open pilon fracture not requiring bone grafting
- Receiving definitive care at an outside facility
- Unlikely to make follow-up appointments
- Active infection at the time of definitive care
- Unable to provide informed consent prior to definitive care
- Prisoners
- Pregnant patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Missouri - Columbia
Columbia, Missouri, United States, 65201
Actively Recruiting
Research Team
V
Vicki L Jones, MEd
CONTACT
N
Nash Kolb
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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