Actively Recruiting
Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder
Led by The City College of New York · Updated on 2025-12-05
15
Participants Needed
1
Research Sites
41 weeks
Total Duration
On this page
Sponsors
T
The City College of New York
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this open pilot trial is to learn if an adapted version of Cognitive Processing Therapy (CPT), delivered through telehealth, can treat posttraumatic stress disorder (PTSD) in adults who use syringe services programs. The main questions it aims to answer are: * Can the intervention be done in syringe services programs? * Are syringe services program clients and staff open to the intervention? * Can the intervention lower PTSD symptoms and help participants keep taking their medication for opioid use disorder (ex. Buprenorphine or methadone)? Participants will: * Attend 4-18 tele-delivered CPT sessions at the syringe services program * Complete between-session CPT practice with the support of SSP-based "coaches" * Meet with research staff monthly to complete surveys of their PTSD symptoms, drug use, and mental health
CONDITIONS
Official Title
Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over the age of 18
- Regular syringe services program attendance, at least 4 visits in the past month
- Meeting DSM-5 opioid use disorder criteria
- Prescribed a medication for opioid use disorder in the past 30 days at screening
- Experienced a Criterion A traumatic event as measured by the Life Events Checklist for DSM-5
- PTSD symptoms consistent with diagnosis, indicated by a score of 31 or greater on the PTSD Checklist for DSM-5
- Ability to understand English
- Consent to audio record assessment interviews and video record teletherapy sessions for research
- Ability to provide informed consent
You will not qualify if you...
- High risk for suicidal thoughts or behaviors making participation unsafe, as measured by the Columbia Suicide Severity Rating Scale
- Current diagnosis of psychotic or bipolar disorder according to DSM-5
- Cognitive impairment that interferes with study procedures
- Currently receiving trauma-focused psychotherapy such as Prolonged Exposure or Cognitive Processing Therapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
OnPoint
New York, New York, United States, 10035
Actively Recruiting
Research Team
T
Teresa Lopez-Castro, PhD
CONTACT
A
Aaron D Fox, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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