Actively Recruiting
Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Led by Nashwa Ahmed · Updated on 2026-02-05
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids. This technique employs a combination of antinociceptive agents targeting various pathways within the central and peripheral nervous systems to achieve effective analgesia. Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive and anxiolytic properties. Only a few prospective randomized controlled trials have specifically examined the postoperative analgesic efficacy of intraoperative dexmedetomidine infusion in patients undergoing spinal surgery, with limited data focusing on this as a primary endpoint. Importantly, no clinical studies have investigated its analgesic impact in patients undergoing spinal surgery under general anesthesia.
CONDITIONS
Official Title
Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients younger than 18 years of age
- Classified as American Society of Anesthesiologists (ASA) Physical Status I or II
- Scheduled for surgical correction of adolescent idiopathic scoliosis
You will not qualify if you...
- Refusal to participate or to allow use of personal data
- Non-idiopathic scoliosis
- Contraindications to commonly used perioperative medications
- ASA Physical Status III or higher
- Presence of neuromuscular disorders or severe cardiac dysfunction
- Requirement for postoperative mechanical ventilation
- Regular use of analgesics or opioids
- History of allergy to opioids or dexmedetomidine
- Diagnosed mental disorders
- Severe hepatic or renal dysfunction
- Coagulopathy or significant pulmonary disease
- Preoperative or postoperative neurological deficits
- Serious arrhythmia, hypotension, or bradycardia requiring stopping dexmedetomidine infusion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Port said university
Port Said, Egypt, 42111
Actively Recruiting
Research Team
N
Nashwa gomaa Ahmed, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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