Actively Recruiting
Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS
Led by Tongji Hospital · Updated on 2025-01-03
480
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects including postoperative lung function and pulmonary complications, pain, gastrointestinal function, nausea/vomiting, cognitive function, and depression/anxiety, intending to expand the dataset and application prospects in this field, and increase feasibility experience.
CONDITIONS
Official Title
Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA grades 1-2
- Age greater than 18 years and less than 70 years
- Male or female patients
- Planned video-assisted thoracoscopic surgery (VATS) for lung nodule under general anesthesia
- Voluntarily agree to participate and provide informed consent
You will not qualify if you...
- Surgery aborted
- Serious adverse events, complications, or special physiological changes during perioperative period that prevent continuation
- Expanded surgical scope including complex lung segment or lobectomy, enlarged incision thoracoscopic surgery, pulmonary blood vessel or airway reconstruction, partial pericardiectomy, or conversion to thoracotomy
- Need for a second operation within one month
- Patient or guardian requests withdrawal
- Other reasons deemed by researchers to discontinue the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tongji Hospital
Wuhan, Hubei, China
Actively Recruiting
Research Team
H
Hui Xu, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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