Actively Recruiting
Opioid-Sparing Joint Replacement
Led by Emory University · Updated on 2026-04-17
120
Participants Needed
1
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate whether an opioid-sparing postoperative pain regimen can reduce opioid consumption and maintain effective pain control in adults undergoing anterior total hip arthroplasty for osteoarthritis. The main questions it aims to answer are: * Does an opioid-limited regimen result in lower postoperative opioid use compared with a standard opioid prescription? * Does the opioid-limited regimen provide comparable or improved postoperative pain control and patient satisfaction?
CONDITIONS
Official Title
Opioid-Sparing Joint Replacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of hip osteoarthritis requiring primary arthroplasty
- Scheduled to undergo anterior total hip arthroplasty (THA)
- Able to comply with study procedures and follow-up visits
- Able to provide informed consent
You will not qualify if you...
- Concurrent significant injuries to other bones or organs
- Local infection at or near the surgical site
- Preoperative opioid use within 4 weeks prior to surgery
- History of severe heart disease (NYHA Class II or higher), renal failure, or liver dysfunction
- Chronic liver disease
- Neurological or psychiatric conditions that may influence pain perception
- Pregnancy
- History of alcohol or medication abuse
- Inability to take NSAIDs
- Use of postoperative DVT prophylaxis other than aspirin 81 mg twice daily
- Diabetes mellitus with HbA1c > 8.0%
- Diagnosis of chronic pain syndrome or fibromyalgia
- Pain Catastrophizing Scale (PCS) score > 29
- Any condition that, in the investigator's judgment, may interfere with adherence to study procedures or follow-up
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Emory University Orthopedics and Spine Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
Research Team
A
Ajay Premkumar, MD
CONTACT
D
Darrell Favors
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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