Actively Recruiting
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
Led by University of Florida · Updated on 2026-01-14
45
Participants Needed
1
Research Sites
278 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
CONDITIONS
Official Title
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals fluent in English
- Recreational use of opioids reported
- Within 20% of ideal body weight
- No chronic pain on most days during the past 3 months
- Systolic blood pressure <= 140 and diastolic blood pressure <= 90
- Heart rate <= 90 beats per minute
- Normal electrocardiogram (EKG) reading
- Bloodwork showing no major health contraindications
You will not qualify if you...
- Significant current physical disease or major psychiatric disorder
- Current interest in drug abuse treatment
- Pregnant or nursing women
- Any comorbid illicit substance use disorders or clinically significant withdrawal for any abused drug excluding nicotine and caffeine
- Conditions unsafe for MRI such as implanted electrical devices, metallic clips or pins, history of working with metal (unless MRI safe), or claustrophobia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
Research Team
L
Lauren Nieder
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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