Actively Recruiting
A Randomized Control Trial for Opioid Use After Laparoscopic Salpingectomy
Led by Johns Hopkins University · Updated on 2026-06-03
38
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare pain control methods after minimally invasive tubal sterilization procedures in women aged 18 and older. It evaluates whether a non-opioid pain management plan is as effective as the standard regimen that includes opioids. The goal is to see if pain can be managed without opioids, reducing the need for opioid prescriptions after laparoscopic salpingectomy. Participants are randomly assigned to one of two groups. One group receives the common post-operative pain treatment including acetaminophen, ibuprofen, and oxycodone as needed. The second group receives only acetaminophen and ibuprofen without an opioid prescription initially but may receive oxycodone if additional pain relief is needed. All patients are advised to use acetaminophen and ibuprofen regularly for the first 72 hours after surgery. During the study, participants report their pain levels on post-operative days 1 and 7. Researchers also assess satisfaction with pain relief and mobility, total narcotic use, side effects related to opioids, and any additional pain medication requests or unplanned medical care within 30 days after surgery. The study monitors these outcomes to understand the effectiveness and safety of non-opioid pain control compared to opioid use after surgery.
CONDITIONS
Brief Title
Opioid Use After Laparoscopic Salpingectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with one or both fallopian tubes
- Age 18 years old and above
- Undergoing minimally invasive (laparoscopic or robotic) unilateral or bilateral salpingectomy or other tubal sterilization as the primary procedure
- Salpingectomy or tubal sterilization performed for benign reasons
- Agreeing to participate in the study
You will not qualify if you...
- Having chronic pain syndromes such as fibromyalgia
- Current long-term opioid use lasting more than three months
- Conversion to open surgery (laparotomy)
- Allergy or contraindication to acetaminophen, oxycodone, or other prescribed medications
- Salpingectomy performed with major gynecologic surgery like hysterectomy
- Salpingectomy done to treat ectopic pregnancy
- History of gastritis or gastrointestinal bleeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to discharge after surgery
Participants undergo a minimally invasive laparoscopic salpingectomy or tubal sterilization procedure and begin post-operative pain management.
1 visit (in-person) on the day of surgery
Duration - Up to 7 days post-operative
Participants receive either an opioid-based or non-opioid post-operative pain control regimen with Acetaminophen and Ibuprofen scheduled around the clock for the first 72 hours and as needed thereafter. Participants in the non-opioid group may receive opioids if additional pain medication is needed.
1 baseline visit at discharge and 2 follow-up visits on post-operative day 1 and day 7
Duration - Up to 30 days post-operative
Participants are monitored for pain control satisfaction, mobility, narcotic consumption, opioid-related side effects, and any additional medical care requests related to post-surgical pain for up to 30 days after surgery.
Approximately 2 follow-up visits within 30 days after surgery
Trial Site Locations
Total: 1 location
1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
M
Mostafa Borahay, MD
S
Shannon Osborne, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here