Actively Recruiting
Opioid Use Disorder and Pain
Led by Yale University · Updated on 2025-02-28
180
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse? Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use. Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.
CONDITIONS
Official Title
Opioid Use Disorder and Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 21 and 60 years old
- Able to read and write and provide written informed consent
- Meet DSM-5 criteria for moderate to severe opioid use disorder and currently seeking or receiving treatment for OUD (for OUD group)
- Use non-prescribed opioids weekly or more (for regular opioid users)
- Physically healthy with no major medical illnesses, history of head injury, or neurological illness
- No plans to move out of state in the next 12 months
- Speak English
- Enrolled in an inpatient or outpatient OUD treatment program for at least 4 weeks (for OUD treatment group)
- Demographics matching OUD participants (for healthy controls)
- Able to lie comfortably flat on back for up to 2 hours in MRI scanner
- Body weight within MRI scanner limit (up to 550 lbs)
You will not qualify if you...
- Significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, or thyroid disease
- History of head injury with loss of consciousness over 30 minutes
- Current or past major psychiatric disorder (other than opioid or nicotine use disorders) requiring hospitalization or daily medications over 4 weeks
- Current depressive or anxiety symptoms requiring treatment
- Presence of foreign ferromagnetic metal objects or other MRI contraindications
- Previous work in metal industry or with metal shavings posing MRI risk
- Pregnant or lactating women
- Unable or unwilling to lie flat in MRI scanner for up to 2 hours
- Body weight exceeding 550 lbs MRI scanner limit
- Still experiencing significant withdrawal symptoms
- History or current Axis I disorder (except nicotine use) for healthy controls
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Connecticut Mental Health Center, S105
New Haven, Connecticut, United States, 06519
Actively Recruiting
Research Team
T
Thang M Le, PhD
CONTACT
C
Chiang-shan R Li, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here