Actively Recruiting
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
Led by Wayne State University · Updated on 2025-12-30
24
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
Sponsors
W
Wayne State University
Lead Sponsor
H
Henry Ford Health System
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this study, the investigators will measure affective, neurocognitive and behavioral outcomes related to chronic use of opioids and benzodiazepines (screening phase), and in response to the administration of the opioid morphine, the benzodiazepine alprazolam, morphine then alprazolam, alprazolam then morphine, morphine+alprazolam simultaneously, and placebo (laboratory pharmacology experiment). The latter will enable the investigators to assess the effects of an opioid alone, benzodiazepine alone, concurrent and simultaneous administration of opioid+benzodiazepine, relative to a placebo control.
CONDITIONS
Official Title
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must have self-reported past 10-year use of opioid and sedative drugs or alcohol use on at least 3 separate days in the past month
- May have mild to moderate Opioid Use Disorder or Sedative Use Disorder
- Must not be seeking treatment for substance use problems
- Must be in good overall health
You will not qualify if you...
- Current severe psychiatric disorders such as psychosis, bipolar disorder, or severe depression
- Severe substance use disorder for any substance
- Past-month prescription of benzodiazepines or opioids
- Past-year overdose or suicide attempt/ideation
- Cognitive impairment (IQ less than 80)
- Neurological, cardiovascular, pulmonary, or systemic diseases
- Body mass index over 38 kg/m2
- Females who are pregnant, lactating, or heterosexually active without birth control
- Treatment with methadone, buprenorphine, or naltrexone
- Past 30-day use of contraindicated medications
- Positive breath alcohol sample over 0.02%
- Positive urine test for methadone, cocaine, amphetamines, or barbiturates
- Intolerance of lactose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tolan Park Medical Building
Detroit, Michigan, United States, 48201
Actively Recruiting
Research Team
M
Mark K Greenwald, PhD
CONTACT
H
Heidi Aguas
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here