Actively Recruiting
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Led by Duke University · Updated on 2026-01-09
60
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).
CONDITIONS
Official Title
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 21 years or older who smoke cigarettes daily
- Chronic non-cancer musculoskeletal pain due to structural changes (e.g., low back pain, osteoarthritis)
- Stable office-based buprenorphine treatment for opioid use disorder for at least 30 days
- Self-reported smoking of at least 10 cigarettes per day
- Expired breath carbon monoxide level greater than 8 ppm
- Smartphone capable of running ecological momentary assessment software
- Willingness to consider quitting smoking
You will not qualify if you...
- Pain caused by cancer
- Other significant health problems
- Major surgery within the past 6 months or planned surgery during the study period
- Current disability litigation
- Use of electronic cigarettes or other non-cigarette tobacco products more than 9 of the past 30 days
- Current use of nicotine replacement therapy or other smoking cessation treatments
- Current daily or near-daily cannabis use
- History of psychotic disorder
- Acute suicidality or unstable psychiatric disorder
- Positive pregnancy test
- Actively seeking smoking cessation treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
North Pavilion
Durham, North Carolina, United States, 27705
Actively Recruiting
Research Team
C
Clinical Research Coordinator
CONTACT
C
Clinical Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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