Actively Recruiting
Optic Nerve Sheath Ultrasound in Giant Cell Arteritis
Led by Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Updated on 2025-08-07
285
Participants Needed
6
Research Sites
186 weeks
Total Duration
On this page
Sponsors
C
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Lead Sponsor
M
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Sonographic Assessment of the Optic Nerve Sheath in Giant Cell Arteritis (SONIC-GCA) study will evaluate the performance of the optic nerve sheath diameter (ONSD), measured via ultrasound, to diagnose and monitor GCA. SONIC-GCA builds upon our previous pilot studies and will answer the following questions: 1. What is the performance of ONSD to identify patients with new-onset, active GCA? 2. Is ONSD useful for monitoring GCA relapses during follow-up? 3. What is the intra- and interobserver reliability of ONSD measurements? 4. Does ONSD differ between patients with and without GCA-related retinal findings?
CONDITIONS
Official Title
Optic Nerve Sheath Ultrasound in Giant Cell Arteritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 50 years
- Referral to a GCA clinic for suspected, new-onset Giant Cell Arteritis
- Ability to understand and willingness to sign informed consent
- Willingness to comply with study visits and procedures
You will not qualify if you...
- Referral for suspected GCA relapse
- Use of systemic glucocorticoids for 14 or more consecutive days orally in the previous 30 days, or 7 or more days if intravenous glucocorticoids were given
- Use of any conventional or biologic immunosuppressive therapy
- History of retinal diseases, optic nerve diseases, demyelinating diseases, normotensive hydrocephalus, intracranial tumors, or conditions causing intracranial hypertension
- Any condition preventing optic nerve sheath ultrasound or fundoscopy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
St-Joseph's Health Care London
London, Ontario, Canada, N6A 4V2
Not Yet Recruiting
2
Sinai Health - Toronto
Toronto, Ontario, Canada, M5G 1X5
Not Yet Recruiting
3
MUHC - McGill University
Montreal, Quebec, Canada, H3G 1A4
Not Yet Recruiting
4
Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, Canada, H4J1C5
Actively Recruiting
5
CIUSSS de l'Est-de-l'ile de Montreal
Montreal, Quebec, Canada, H4R 3K6
Not Yet Recruiting
6
CIUSSS de l'Estrie - CHUS
Sherbrooke, Quebec, Canada, H1T 2M4
Not Yet Recruiting
Research Team
J
Jean-Paul Makhzoum, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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