Actively Recruiting
Optical Correction and Visual Functions of Adults With Amblyopia
Led by Centre for Eye and Vision Research · Updated on 2026-03-18
36
Participants Needed
2
Research Sites
259 weeks
Total Duration
On this page
Sponsors
C
Centre for Eye and Vision Research
Lead Sponsor
T
The Hong Kong Polytechnic University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Amblyopia is a developmental anomaly resulting from abnormal visual experiences in early life. Amblyopia causes reduced visual acuity in the absence of a pathology. Adult sensory systems are believed to be structurally invariant beyond early, critical periods of development. However, recent evidence suggest that visual functions in adults with amblyopia can be improved with optical correction alone. This study aims to investigate whether improvements in best corrected visual acuity and other visual functions can result following appropriate optical correction in adults with amblyopia. Functional measures relating to vision, binocular vision, and eye movements will be used to assess the efficacy of refractive correction for improving vision. This study will help us better understand the improvements in visual functions following optical correction, as well as the mechanisms underlying neuroplasticity in adults with amblyopia.
CONDITIONS
Official Title
Optical Correction and Visual Functions of Adults With Amblyopia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 39 years old
- Anisometropic amblyopia or mixed mechanism amblyopia involving strabismus and anisometropia
- Best corrected visual acuity (BCVA) in the amblyopic eye between 0.3 and 1.0 logMAR
- BCVA in the non-amblyopic eye of 0.1 logMAR or better and a difference of 2 or more logMAR lines between eyes
- A difference of 1.00 diopter or more between current prescription and study spectacles
- Good general health
You will not qualify if you...
- Other eye diseases causing reduced vision
- Presbyopia based on accommodation ability
- Cannot tolerate prescribed spectacles (e.g., due to aniseikonia)
- Cannot use cycloplegic eye drops
- Currently receiving amblyopia treatment or therapy
- Cannot understand test instructions or give consent
- Eccentric fixation
- More than -6.00 diopters of myopia in either eye with glasses
- Bilateral amblyopia
- Amblyopia not caused by strabismus or anisometropia
- Current or past psychiatric, visual, or neurological disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Waterloo
Waterloo, Ontario, Canada, N2L 3G1
Actively Recruiting
2
Centre for Eye and Vision Research Limited
Hong Kong, Guangdong, Hong Kong, 00000
Actively Recruiting
Research Team
B
Benjamin Thompson, PhD
CONTACT
K
Ken WS Tan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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