Actively Recruiting
OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels
Led by Inova Health Care Services · Updated on 2026-04-22
250
Participants Needed
7
Research Sites
322 weeks
Total Duration
On this page
Sponsors
I
Inova Health Care Services
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to develop and refine a microRNA (miR) biomarker panel that can be used to phenotype net immune state after heart transplantation using circulating miRs (associated with drug doses and levels). These miRs will be used to characterize the overall immune state in adult heart transplant patients and predict patients that will go on to develop infection and rejection. MicroRNAs (miRs) are small, non-coding RNA molecules that regulate gene expression and serve as molecular biomarkers found in the circulation.
CONDITIONS
Official Title
OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3E�3D 18 years at enrollment
- Received orthotopic heart transplant (OHT) within the prior 1 month �B1 2 weeks
- Planned follow-up at the transplant center for a minimum of one year
- Able and willing to comply with the study visit schedule, procedures, and requirements
You will not qualify if you...
- Recipient of a multi-organ transplant
- History of prior solid organ transplant before the index heart transplant
- Ongoing mechanical circulatory support or hemodynamic instability (e.g., inotrope or vasopressor therapy)
- Ongoing need for renal replacement therapy and/or dialysis
- Active infection requiring hospitalization, antimicrobial therapy, or reduction in immunosuppression
- Active rejection being treated with intravenous medications or plasmapheresis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
2
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
3
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
4
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
5
Vanderbilt University
Nashville, Tennessee, United States, 37232
Actively Recruiting
6
Baylor University Medical Center
Dallas, Texas, United States, 75246
Actively Recruiting
7
Inova Health System
Falls Church, Virginia, United States, 22042
Not Yet Recruiting
Research Team
P
Palak Shah, MD
CONTACT
S
Stephanie Wolak, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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