Actively Recruiting
Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs
Led by Inova Health Care Services · Updated on 2026-03-25
150
Participants Needed
7
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to discover circulating microRNAs (associated with drug doses and levels) that can be used to characterize the overall immune state in pediatric heart transplant patients and predict patients that will go on to develop infection and rejection. MicroRNAs (miRs) are small, non-coding RNA molecules that regulate gene expression and serve as molecular biomarkers found in the circulation.
CONDITIONS
Official Title
Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 64 18 years at time of transplant listing
- Subject is within 10-50 days post-orthotopic heart transplant at time of enrollment
- Planned follow-up at the transplant center for a minimum of one-year
- Caregiver able and willing to comply with the study visit schedule, study procedures, and study requirements
You will not qualify if you...
- Recipient of a multi-organ transplant
- History of prior solid organ transplant before the index heart transplant
- Ongoing mechanical circulatory support or hemodynamic instability after transplant
- Active infection requiring either a) hospitalization or b) treatment with antimicrobial drugs (not including prophylaxis or suppressive antibiotics given after transplant)
- History of treated rejection prior to study enrollment
- Inability to collect specified blood volume after enrollment and prior to 50 days post-transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
2
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
3
Columbia University
New York, New York, United States, 10032
Actively Recruiting
4
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
5
Vanderbilt University
Nashville, Tennessee, United States, 37232
Actively Recruiting
6
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
7
Inova Health System
Falls Church, Virginia, United States, 22042
Not Yet Recruiting
Research Team
P
Palak Shah, MD
CONTACT
S
Stephanie Wolak, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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