Actively Recruiting

Phase Not Applicable
Age: 18Years - 89Years
All Genders
ID06731998

Evaluating Optimal Perioperative Pain Management: A Randomized Trial of Laparoscopic Transversus Abdominis Plane Block with Local Anesthetic, LapTAP Alone, and Local Anesthetic Alone in Minimally Invasive Oncologic Surgery

Led by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Updated on 2025-09-18

48

Participants Needed

1

Research Sites

26 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effectiveness of three different routine pain management methods used during minimally invasive cancer surgery. This study compares Laparoscopic Transversus Abdominis Plane block (LapTAP) combined with Local Anesthetic (LA), LapTAP alone, and LA alone. The trial aims to improve postoperative pain control in patients undergoing various types of minimally invasive oncologic surgeries by assessing these methods in a prospective, randomized control trial. Participants will be randomly assigned to one of three groups: receiving LapTAP with LA, LapTAP alone, or LA alone during their surgery. The LapTAP procedure involves injecting ropivacaine into the fascial plane between abdominal muscles, while LA is administered around surgical port sites. All patients will receive standard pre- and post-operative care according to clinical guidelines, with the study treatments given during the surgery. During the study, researchers will collect data from medical records for 24 hours post-surgery and until hospital discharge, typically about one week. They will monitor pain scores hourly for 24 hours and at discharge, opioid consumption, recovery analgesic time, side effects, and patient satisfaction with pain management. Participation ends at hospital discharge, with no additional long-term follow-up beyond this period.

CONDITIONS

Brief Title

Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery

Who Can Participate

Age: 18Years - 89Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Male or female patients aged 18 to 89 years
  • Scheduled for elective minimally invasive oncologic surgery on hepatic, gastric, biliary, pancreatic, gynecologic, colorectal, or other gastrointestinal areas
  • Provided informed consent to participate
  • American Society of Anesthesiologists (ASA) physical status I, II, or III
  • Surgery expected to last more than 1 hour but less than 8 hours
  • Able to understand and self-report pain using the designated pain Visual Analog Scale
Not Eligible

You will not qualify if you...

  • Age less than 18 or 90 and older
  • Pre-existing liver dysfunction or cirrhosis
  • ASA classification IV or higher
  • Chronic pain disorders or long-term opioid or analgesic therapy
  • Known allergy or contraindication to study drugs or procedures
  • Cognitive impairments or psychiatric conditions interfering with pain assessment or consent
  • Inability to understand English for consent and study information
  • Major surgery within the last 6 months
  • Pregnant female patients
  • Currently enrolled in another clinical trial that may affect outcomes

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Surgery duration plus up to 1 week post-surgery

Participants undergo minimally invasive oncologic surgery and receive one of three pain management interventions: Laparoscopic Transversus Abdominis Plane block with Local Anesthetic, LapTAP alone, or Local Anesthetic alone.

1 surgery visit and daily assessments up to hospital discharge (on average 1 week)

Follow-up

Duration - Up to 1 week post-surgery

Participants are monitored for pain control effectiveness, opioid consumption, adverse events, and patient satisfaction until hospital discharge, approximately 1 week after surgery.

Daily assessments during hospital stay until discharge

Trial Site Locations

Total: 1 location

1

AHN West Penn Hospital

Pittsburgh, Pennsylvania, United States, 15224

Actively Recruiting

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Research Team

C

Casey Allen, MD

A

AHN Clinical Trials Contact

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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Published Research Related To This Trial

Transversus abdominis plane block versus local anaesthetic wound infiltration for postoperative analgesia: A systematic review and meta-analysis.

Qingduo Guo, Rui Li, Lixian Wang...

https://pubmed.ncbi.nlm.nih.gov/26770326

Laparoscopic-Guided Transversus Abdominis Plane Block for Postoperative Pain Management in Minimally Invasive Surgery: Systematic Review and Meta-Analysis.

Hytham Ks Hamid, Sameh H Emile, Alan A Saber...

https://pubmed.ncbi.nlm.nih.gov/32502615

Transversus Abdominis Plane Block VS. Local Wound Infiltration for Elective Minimally Invasive Cholecystectomy in Children: A Prospective Randomized Trial.

Sindhu Mannava, Niloufar Hafezi, Farheen Turk...

https://pubmed.ncbi.nlm.nih.gov/37863700

Transversus abdominis plane block after ambulatory total laparoscopic hysterectomy: randomized controlled trial.

Gustavo A Calle, Claudia C López, Enrique Sánchez...

https://pubmed.ncbi.nlm.nih.gov/24575769

Efficacy of laparoscopic-guided transversus abdominis plane block for patients undergoing robotic-assisted gynaecologic surgery: A randomised control trial.

Anupama Rajanbabu, Nitu Puthenveettil, Akhila Appukuttan...

https://pubmed.ncbi.nlm.nih.gov/31649397

Randomized controlled double-blind trial of transversus abdominis plane block versus trocar site infiltration in gynecologic laparoscopy.

Lena El Hachem, Ethan Small, Peter Chung...

https://pubmed.ncbi.nlm.nih.gov/25088860