Timing of Laparoscopic Gallbladder Removal After Drainage in Adults with Moderate to Severe Acute Cholecystitis Early Versus Late Surgery

What this Trial Is About

This research aims to determine the best timing for laparoscopic cholecystectomy LC after percutaneous cholecystostomy PC in patients with acute cholecystitis grades II and III who cannot undergo surgery immediately due to their condition or other health issues. The study addresses the uncertainty about whether early or delayed surgery reduces recurrence and complications, especially in severe cases, and also evaluates related costs and health impacts. Participants will be randomly assigned to one of two groups an early surgery group receiving LC within 2 weeks of diagnosis preferably within 10 days and a delayed surgery group receiving LC after the 6th week ideally between weeks 6 and 8. Before surgery, all will undergo imaging tests like MRCP or endoscopic ultrasound to check for bile duct stones and may receive antibiotics according to hospital protocols. The PC catheter will remain in place until surgery and be removed during the operation. During the study, researchers will collect detailed medical information including patient demographics, pre-existing conditions, treatment details, surgical techniques, complications, and recovery outcomes. They will measure the recurrence rate of cholecystitis six months after PC and monitor morbidity and mortality at 30 and 90 days post-surgery. Follow-up includes reviewing medical records and clinical notes to assess patient progress and safety throughout the trial period.

Optimal Timing for Laparoscopic Cholecystectomy After Cholecystostomy in Acute Cholecystitis Tokyo II/III Setting