Actively Recruiting
Optimal Ventilation for Cardiac Arrest
Led by Children's Hospital of Philadelphia · Updated on 2025-10-08
1530
Participants Needed
20
Research Sites
234 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Philadelphia
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.
CONDITIONS
Official Title
Optimal Ventilation for Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
- Received at least 1 minute of CPR
You will not qualify if you...
- Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care)
- Brain death determination prior to the CPR event
- Out-of-hospital cardiac arrest was the reason for initial hospital admission
- Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
CHOC
Orange, California, United States, 92868
Actively Recruiting
2
Lucile Packard Children's Hospital Stanford
Palo Alto, California, United States, 94304
Actively Recruiting
3
Children's Hospital Colorado
Denver, Colorado, United States, 80045
Actively Recruiting
4
Nemours Children's Health
Wilmington, Delaware, United States, 19803
Actively Recruiting
5
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30303
Actively Recruiting
6
Riley Children's Health
Indianapolis, Indiana, United States, 46202
Actively Recruiting
7
Stead Family Children's Hospital
Iowa City, Iowa, United States, 52242
Actively Recruiting
8
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
9
Washington University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
10
Cohen Children's Medical Center
New Hyde Park, New York, United States, 11040
Actively Recruiting
11
UNC Children's Hospital
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
12
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
13
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
14
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
15
Dell Children's Medical Center
Austin, Texas, United States, 78723
Actively Recruiting
16
Medical City Children's Hospital
Dallas, Texas, United States, 75230
Actively Recruiting
17
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
18
Children's Hospital of Richmond at VCU
Richmond, Virginia, United States, 23219
Actively Recruiting
19
Seattle Children's
Seattle, Washington, United States, 98105
Actively Recruiting
20
Children's Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
C
CHOP RSC Clinical Research Program Manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
14
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