Actively Recruiting
Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Structural Heart Disease VT
Led by University Hospitals Coventry and Warwickshire NHS Trust · Updated on 2026-04-13
77
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Ventricular tachycardia (VT) is a dangerous heart rhythm disorder that can be life-threatening. This research aims to improve how doctors find the damaged heart areas causing VT episodes in patients with structural heart disease. The study focuses on a new method that detects special heart signals called decrementing evoked potentials (DeEPs) to better guide VT ablation procedures. The goal is to reduce VT episodes in patients who have implantable cardiac defibrillators (ICDs). The treatment being studied is called Optimised DeEP-guided ablation, which uses detailed computer-generated maps to locate and remove diseased heart tissue through controlled heating. This procedure is performed in specialized cardiac catheter laboratories using Abbott intracardiac mapping catheters and Ensite mapping systems. The ablation targets areas identified by DeEP signals. The procedure is part of the patient's standard care, performed either urgently or electively. Participants will be monitored for 12 months after the ablation to assess the procedure's success in preventing VT episodes. Quality of life will be measured before and after treatment using questionnaires. The main outcome measured is the acute success rate from the start to the end of the VT ablation procedure. Patients will receive routine follow-up as part of their care, with the study conducted by multiple cardiac centers in the UK to gather comprehensive data on this new mapping approach.
CONDITIONS
Brief Title
Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Structural Heart Disease VT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- Patients with cardiac implantable electronic devices such as pacemakers, cardiac resynchronisation therapy (CRT), or implantable cardioverter defibrillator (ICD) devices
- Eligible for ventricular tachycardia (VT) ablation as part of standard care, either urgent or elective
- Diagnosis of ischemic heart disease with prior myocardial infarction or other structural heart diseases such as arrhythmogenic cardiomyopathy, dilated cardiomyopathy, hypertrophic cardiomyopathy, sarcoidosis, or myocarditis
- Undergoing catheter VT ablation using Abbott intracardiac mapping catheter and Ensite intracardiac mapping system
You will not qualify if you...
- Lacks capacity to provide informed consent
- Has New York Heart Association (NYHA) class IV heart failure
- Life expectancy less than 12 months
- Implanted with a ventricular assist device
- Presence of mobile intracardiac thrombus
- Reversible cause of ventricular tachycardia
- Women who are pregnant or nursing
- Has both mechanical aortic and mitral valves
- Enrolled in another interventional clinical study that increases risk or is inappropriate for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - From the start to the end of the VT ablation procedure.
Participants undergo Optimised DeEP-guided ventricular tachycardia ablation using catheter mapping as part of the procedure.
1 procedure visit (in-person)
Trial Site Locations
Total: 1 location
1
University Hospitals Coventry & Warwickshire NHS Trust
Coventry, West Midlands, United Kingdom, CV2 2DX
Actively Recruiting
Research Team
S
Shivam Joshi
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here