Defining Parameters to Optimize Neurostimulation for the Treatment of Pediatric Depression

What this Trial Is About

This research investigates different parameters of intermittent theta burst transcranial magnetic stimulation (iTBS), a type of repetitive TMS used to alter brain activity and promote brain plasticity. The study focuses on how the shape and duration of electromagnetic pulses during iTBS affect the brain's ability to reorganize itself, aiming to improve treatment methods for depression that does not respond to usual therapies. Participants will receive three different iTBS protocols, each separated by a week. The protocols involve different pulse shapes and durations: monophasic pulses, biphasic pulses, and long monophasic pulses. Each protocol uses pulses delivered at 80% of the resting motor threshold, with specific frequency and timing settings. The sequence of these protocols will be randomized for each participant. During the study, brain activity will be monitored before and after each iTBS session to measure cortical plasticity, with assessments every five minutes up to one hour post-intervention. Participants will be involved in multiple sessions with these measurements to understand the effects of each protocol. The study will also monitor participant health and any reactions throughout the process, with the total participation duration spanning several weeks due to the multiple study visits and washout periods.

Optimization of ITBS for Depression