Actively Recruiting
Optimization of NIBS for Treatment of Addiction
Led by Case Western Reserve University · Updated on 2026-03-04
126
Participants Needed
3
Research Sites
343 weeks
Total Duration
On this page
Sponsors
C
Case Western Reserve University
Lead Sponsor
H
Highland Instruments, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.
CONDITIONS
Official Title
Optimization of NIBS for Treatment of Addiction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide informed consent
- Age 18-85 years
- Diagnosis of opioid use disorder (DSM-5) with ongoing non-prescription opioid use confirmed by self-report and urine toxicology
- Report current opioid craving
- Enrolled in a certified Opioid Treatment Program and receiving methadone maintenance treatment
- Stable methadone dose prior to enrollment
- Reside locally with no plans to relocate during the study
You will not qualify if you...
- Are pregnant
- Have frequent illicit stimulant use or acute stimulant intoxication
- Are using substances or medications that may interfere with study assessments (e.g., stimulant medications, buprenorphine-based therapies, naltrexone)
- Have significant neurological conditions (e.g., stroke, epilepsy, brain tumor), abnormal EEG findings, history of brain surgery, significant head injury, or unexplained syncope
- Have contraindications to noninvasive brain stimulation (e.g., metal in the head, implanted brain devices)
- Have moderate to severe depression or active suicidal ideation/behavior
- Have active malignancy
- Consume substances that could confound opioid toxicology results (e.g., poppy-seed products)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University of Illinois Health/ University of Illinois at Chicago
Hinsdale, Illinois, United States, 60612
Actively Recruiting
2
Spaulding Rehabilitation Hospital - 5th Floor - Neuromodulation Center
Cambridge, Massachusetts, United States, 02138
Actively Recruiting
3
University Hospitals Cleveland Medical Center/ Dahms Clinical Research Unit
Cleveland, Ohio, United States, 44106-1716
Actively Recruiting
Research Team
K
Kimberly Bass, RN
CONTACT
M
Mario Becerra, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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