Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06072339

Optimization of Positive End Expiratory Pressure by Use of Pulmonary Ultrasound for Patients With Blunt Chest Trauma Treated by Non-Invasive Ventilation (Opti-PEP).

Led by University Hospital, Montpellier · Updated on 2024-10-04

40

Participants Needed

1

Research Sites

105 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is an open-label, randomized controlled study comparing two non-invasive ventilation initiation strategies.Patients may be included if they present with acute respiratory failure related to blunt chest trauma.The intervention group will benefit from the use by the physiotherapist of pulmonary ultrasound for the adjustment of Positive End Expiratory Pressure (PEEP) during the 1st session. The conventional group will benefit from the non-invasive ventilation according to the current care.

CONDITIONS

Official Title

Optimization of Positive End Expiratory Pressure by Use of Pulmonary Ultrasound for Patients With Blunt Chest Trauma Treated by Non-Invasive Ventilation (Opti-PEP).

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 18 or more
  • Admitted to intensive care or continuing care for 72 hours or less for blunt chest trauma, defined by the presence of at least one of the following elements on the initial CT scan: fracture(s) of rib(s) / fracture(s) of the sternum / pulmonary contusion / hemothorax
  • Acute hypoxemic respiratory failure defined by the administration of oxygen at least 3 L/min with nasal cannula or FiO2≥30% if high flow oxygen therapy.
  • Patient with a functional arterial catheter for blood tests
Not Eligible

You will not qualify if you...

  • Acute respiratory distress, defined by the presence of at least one of the following clinical signs: respiratory rate ˃ 35 / use of accessory inspirators / paradoxal abdominal or thoracic motion
  • Imminent need for invasive mechanical ventilation
  • Usual contraindication to non-invasive ventilation (undrained pneumothorax, trauma to the face, vigilance disorders, digestive bleeding, hemodynamic instability, intolerance)
  • Hypercapnia (PaCO2˃45mmHg)
  • Patient unable to cooperate, communicate
  • Therapeutic limitation
  • Expected length of stay ≤ 48h
  • Severe head trauma
  • Pregnant or breastfeeding women
  • Participation in other clinical research related to respiratory failure/respiratory therapy
  • Vulnerable people
  • Protected adults, under guardianship or curatorship, or unable to give consent
  • Non-affiliated person or beneficiary of a social security scheme
  • Absence of free, informed and written consent, signed by the participant and the investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

UH of Montpellier

Montpellier, France, 34295

Actively Recruiting

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Research Team

D

David CHAPEAU, Physiotherapist

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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