Actively Recruiting
Optimized Diagnosis and Precision Medicine of MODY
Led by Taichung Veterans General Hospital · Updated on 2023-11-01
1500
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
T
Taichung Veterans General Hospital
Lead Sponsor
N
National Health Research Institutes, Taiwan
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observation is to establish a complete registry for the clinical manifestations, environment, genetic, and other related gene variation information of young-onset diabetic patients. Moreover, according to the physiological and pathological mechanisms of different genes, the impact on the clinical characteristics of diabetes, the therapeutic response to drugs, and the impact on complications will be analyzed. The main questions are: 1. The distribution of different types of MODY 2. The phenotypes and clinical characteristics of different types of MODY 3. Response to antidiabetic drugs among different types of MODY Once the participant is enrolled, their questionnaire information (including disease course and development, health history, family history, drug history, etc.), medication, outpatient/inpatient medical history, etc. will be collected and logged in. Blood and urine samples will also be collected for biochemical tests genetic testing, etc. At the same time, the investigators will conduct a continuous follow-up on a regular basis (3 months, 6 months, 12 months, 24 months, and 5 years after the study subject is enrolled). Young-onset type 2 diabetes will be compared to see the difference in clinical presentations and responses to antidiabetic drugs.
CONDITIONS
Official Title
Optimized Diagnosis and Precision Medicine of MODY
Who Can Participate
Eligibility Criteria
You may qualify if you...
-
Case Group Diagnosis of diabetes at or before 25 years of age. BMI (Body Mass Index) of 25 kg/m² or lower. Having at least one parent diagnosed with type 2 diabetes.
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Family Group Direct blood relatives of the case group, including brothers and sisters of the case group, who have contacted the research team through the subjects.
Expressing willingness to participate in this study after granting informed consent.
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Control Group Diagnosis of diabetes occurred at or before the age of 40, and the individual lacks typical MODY (Maturity-Onset Diabetes of the Young) characteristics.
At least one parent has been diagnosed with type 2 diabetes.
You will not qualify if you...
- Confirmed Diagnosed with type 1 diabetes.
- Under 18 years of age.
- Unable to personally provide informed consent.
- Patients with unrelieved leukemia.
- Patients who have undergone chemotherapy or radiation therapy for cancer within the last 12 months.
- Cases that have received a blood transfusion within the last six months.
- Unwilling or unable to continue treatment follow-up at this hospital.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Taichung veterans general hospital
Taichung, Taiwan, 407
Actively Recruiting
Research Team
Y
Yi-Jing Sheen, MD. PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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