Actively Recruiting
Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)
Led by University of Illinois at Urbana-Champaign · Updated on 2024-09-20
72
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults. Our research team will evaluate three different groups: the first group will be chosen using a predictive analytics model that predicts who will benefit most from the MIND diet, the second group will follow the MIND diet without being pre-selected, and the third group will eat a standard healthy diet to serve as a comparison. The main questions it aims to answer are: Does the MIND diet improve cognitive performance and heart health relative to a control diet? How does the health impact of the MIND diet in participants pre-identified through predictive analytics compare to those without such pre-selection? Which of the three groups - predictive analytics selected MIND diet group, standard MIND diet group, or healthy control - demonstrate the most significant improvements in cognitive and cardiovascular health over the course of the trial? Participants will: Consume one meal that follows the MIND diet or a control meal every day for 3 months. Visit the lab before and after the 3 months of meals for tests. Keep a record of the food they eat during the study.
CONDITIONS
Official Title
Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 45 and 64 years
- Vision is 20/20 or corrected to 20/20
- No food allergies or intolerances
- Not pregnant, breastfeeding, or have given birth in the past 12 months
- Do not smoke, use tobacco, or abuse drugs
- No liver or gastrointestinal diseases, hepatitis, HIV, or cancer
- Not taking oral hypoglycemic agents or insulin
- No history of malabsorptive or bariatric surgery
- Cognitively intact with no prior neurological disease diagnosis
- Able to consume the study meals
- Not enrolled in another dietary, exercise, or medication study during the trial
You will not qualify if you...
- Participant does not consent
- Age below 45 or above 64 years
- Vision is not 20/20 or corrected
- Has food allergies or intolerances
- Pregnant, breastfeeding, or given birth in the past 12 months
- Smoke, use tobacco, or abuse drugs
- Diagnosed with liver or gastrointestinal diseases, hepatitis, HIV, or cancer
- Currently taking oral hypoglycemic agents or insulin
- History of malabsorptive or bariatric surgery
- Cognitively impaired or diagnosed with neurological disease
- Unable to consume the study meals
- Enrolled in another dietary, exercise, or medication study
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Illinois at Urbana-Champaign
Urbana, Illinois, United States, 61801
Actively Recruiting
Research Team
N
Naiman Khan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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