Actively Recruiting
Optimizing Brain Excitability in Depression
Led by Stanford University · Updated on 2026-02-10
145
Participants Needed
2
Research Sites
214 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to improve depression treatment by establishing reliable prefrontal excitability markers through Targeting with Automated Real-time Guidance for Enhancing TEPs (TARGET).
CONDITIONS
Official Title
Optimizing Brain Excitability in Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women, ages 18 to 65
- Diagnosis of major depressive disorder confirmed by Structured Clinical Interview for DSM-5 (SCID-5)
- Currently in a depressive episode as assessed by SCID-5
- Moderate-to-severe depression indicated by Quick Inventory of Depressive Symptoms (QIDS) score between 11 and 20
- Able to understand English well to follow EEG and TMS instructions and clinical assessments
- No current or past neurological disorders
- No seizure disorder or risk of seizures
- Neurosurgical patients with medication-refractory epilepsy admitted for phase II intracranial monitoring, aged 18 to 65, able to understand consent and agree to study participation
You will not qualify if you...
- Contraindications for MRI such as implanted metal
- History of head trauma with loss of consciousness
- History of seizures or use of medications that lower seizure threshold (e.g., olanzapine, chlorpromazine, lithium)
- Presence of neurological or uncontrolled medical disease
- Any unstable medical condition
- Active substance abuse
- Diagnosis of psychotic or bipolar disorder
- Previous failure of Electroconvulsive Therapy (ECT)
- Suicide attempt within the past year
- Currently pregnant or breastfeeding
- Received repetitive Transcranial Magnetic Stimulation (rTMS) treatment in the past six months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Iowa
Iowa City, California, United States, 52246
Actively Recruiting
2
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
J
Jade T Truong, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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