Actively Recruiting
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
Led by University of Michigan · Updated on 2026-02-13
900
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The trial investigates a novel adapted multilevel intervention called D-THIO (Deprescribing Thyroid Hormone In Older Adults) aiming to support reducing or stopping thyroid hormone use in adults aged 65 and older who may be overtreated or misusing thyroid hormone. This study will evaluate how well D-THIO works compared to enhanced usual care in helping providers deprescribe thyroid hormone and reduce overtreatment, while also exploring knowledge and attitudes about deprescribing among providers and patients across multiple sites. D-THIO includes evidence-based pharmaceutical opinion letters sent to providers and educational brochures given to patients, facilitated by clinical champions. Providers are randomized to either receive D-THIO or enhanced usual care, which consists of American Thyroid Association guidelines and brochures. Patients of these providers receive corresponding educational materials. The trial enrolls 150 providers and 750 patients across three sites, with randomization at the provider level. Participants will be monitored through surveys of providers and patients assessing knowledge, attitudes, and discussions about deprescribing up to 12 months after enrollment. Researchers will measure thyroid hormone deprescribing by providers and reductions in overtreatment via medical records 6 months post-enrollment. The study includes interviews with stakeholders to understand implementation factors. Overall participation lasts from enrollment through 6 to 12 months of follow-up, with safety and efficacy assessed through clinical data and surveys.
CONDITIONS
Brief Title
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years and older
- Currently on thyroid hormone therapy with a serum TSH less than 0.5 mIU/L or using thyroid hormone for an inappropriate reason
- English speaking
- No cognitive impairment
You will not qualify if you...
- Diagnosis of thyroid cancer
- Secondary hypothyroidism
- History of total thyroidectomy
- Hospitalization in the past 3 months
- Providers who do not prescribe thyroid hormone
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 months
Participants receive behavioral interventions aimed at supporting thyroid hormone deprescribing, including educational materials and provider support.
1 baseline visit and follow-up surveys between 3 to 12 months post-enrollment
Trial Site Locations
Total: 3 locations
1
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
2
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
3
Henry Ford Health System
Detroit, Michigan, United States, 48202
Actively Recruiting
Research Team
B
Brittany Gay
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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