Actively Recruiting
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
Led by University of Utah · Updated on 2026-02-03
300
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Utah
Lead Sponsor
R
Rutgers University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) combined with patient-centered chronic pain management visits to reduce chronic pain, improve quality of life, and lower opioid-related harms in adults with chronic pain who are on long-term opioid therapy. This Phase 3 trial focuses on managing chronic pain and opioid misuse in a primary care setting. Participants are randomly assigned to one of two groups: one group attends weekly MORE behavioral therapy sessions for eight weeks alongside patient-centered chronic pain management visits with their primary care provider, while the other group receives only the patient-centered chronic pain management visits. MORE integrates mindfulness training, cognitive reappraisal, and positive psychology into a group therapy format. Throughout the study, participants will be assessed at 3, 6, 9, and 12 months for changes in opioid misuse, chronic pain levels, quality of life, opioid dosing, opioid craving, PTSD symptoms, depression, and anxiety. The study uses double masking and includes various evaluations to monitor these outcomes over time. Participants can expect regular follow-up visits and questionnaires as part of their involvement.
CONDITIONS
Brief Title
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Current diagnosis of chronic pain lasting at least 3 months as determined by a physician
- Prescribed long-term opioid therapy for 3 months or more
- Score of 3 or higher on the Pain Enjoyment General Activity scale
- Score of 9 or higher on the Current Opioid Misuse Measure OR history of psychiatric or substance use disorder OR benzodiazepine use OR history of overdose OR patient or physician determination that opioid risks may outweigh benefits
You will not qualify if you...
- Chronic pain caused by cancer
- Active suicidal intent, schizophrenia, or psychotic disorder
- Prior experience with Mindfulness-Based Stress Reduction, Mindfulness-Based Cognitive Therapy, Mindfulness-Based Relapse Prevention, or Mindfulness-Oriented Recovery Enhancement
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants attend weekly Mindfulness-Oriented Recovery Enhancement (MORE) group sessions for eight weeks, and all participants meet with their primary care provider for patient-centered chronic pain management visits.
Weekly visits for 8 weeks
Duration - Up to 12 months
Participants are followed to assess changes in opioid misuse, chronic pain, quality of life, PTSD symptoms, depression, and anxiety at multiple timepoints after treatment.
Visits at 3, 6, 9, and 12 months
Trial Site Locations
Total: 3 locations
1
UCSD Health
La Jolla, California, United States, 92037
Actively Recruiting
2
Rutgers University Primary Care Clinics
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
3
University of Utah Primary Care Clinics
Salt Lake City, Utah, United States, 84112
Actively Recruiting
Research Team
H
Hannah Pfeffer, MSW
T
Thanusha Puvananayagam, MPH
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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