Actively Recruiting
Optimizing Early Nutrition Support in Severe Stroke-2
Led by Wen Jiang-3 · Updated on 2026-03-19
546
Participants Needed
30
Research Sites
149 weeks
Total Duration
On this page
Sponsors
W
Wen Jiang-3
Lead Sponsor
T
Tang-Du Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Post stroke pneumonia (PSP) is one of the common early complications of stroke. Post-stroke infections, in general, are associated with less favorable neurologic outcomes. Aspiration is one of the most feared complications of enteral nutrition and can lead to the occurrence of pneumonia. Severe stroke patients are at high risk for aspiration due to some factors such as the reduced level of consciousness, inability to protect the airway and so on. The purpose of this study is to explore the ideal nutrition support strategy for patient with acute severe stroke to help reduce the incidence of PSP and improve the prognosis.
CONDITIONS
Official Title
Optimizing Early Nutrition Support in Severe Stroke-2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Definite diagnosis of acute stroke with Glasgow Coma Scale (GCS) score of 12 or less or National Institutes of Health Stroke Scale (NIHSS) score of 11 or higher
- Nutritional treatment can be started within 72 hours after stroke symptom onset
- Water Swallowing Test results showing profiles #3 through 5 or presence of disorder of consciousness
- Plan to receive nutritional support treatment for at least 7 days
- Provided informed consent to participate
You will not qualify if you...
- Currently receiving parenteral nutrition support
- Have contraindications to enteral nutrition
- Have a disease with life expectancy less than 7 days
- Admission with signs of infection
- Dementia or severe disability (modified Rankin Scale over 4) before stroke
- Used antibiotics within the previous 7 days
- Diagnosis of subarachnoid hemorrhage or cerebral arteriovenous malformation
- Presence of advanced cancer, severe pulmonary dysfunction (FEV1 less than 50% or moderate to severe acute lung injury), cardiac insufficiency (NYHA class greater than I, EF less than 50%, or significant cardiac abnormalities), severe liver failure (Child-Pugh score 7 or higher), or severe renal failure (glomerular filtration rate 30 mL/min or less or serum creatinine 4 mg/dL or higher)
- Currently participating in another clinical trial
- Pregnant woman
- Considered highly likely not to follow study treatment or follow-up protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 30 locations
1
Chongqing University Three Gorges Hospital
Chongqing, Chongqing Municipality, China, 404100
Actively Recruiting
2
Daping Hospital, The Third Military Medical University
Chongqing, Chongqing Municipality, China
Actively Recruiting
3
Gansu Provincal Central Hospital
Lanzhou, Gansu, China
Actively Recruiting
4
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
Not Yet Recruiting
5
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
Actively Recruiting
6
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China, 550000
Actively Recruiting
7
First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
8
Tongji Hospital
Wuhan, Hubei, China
Actively Recruiting
9
The First Hospital of Changsha City
Changsha, Hunan, China
Not Yet Recruiting
10
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330000
Actively Recruiting
11
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China, 750000
Actively Recruiting
12
Shaanxi Second Provincal People's Hospital
Xi'an, Shaanxi, China, 710000
Actively Recruiting
13
Tangdu Hospital
Xi'an, Shaanxi, China, 710000
Not Yet Recruiting
14
The first affiliated hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710000
Actively Recruiting
15
Xi'an Central Hospital
Xi'an, Shaanxi, China, 710000
Not Yet Recruiting
16
Department of Neurology, Xijing Hospital
Xi'an, Shaanxi, China
Actively Recruiting
17
Shannxi Provincal People's Hospital
Xi'an, Shaanxi, China
Not Yet Recruiting
18
The First Affiliated Hospital of Xi'an Medical University
Xi'an, Shaanxi, China
Actively Recruiting
19
Xi'an Gaoxin Hospital
Xi'an, Shaanxi, China
Actively Recruiting
20
Xi'an No.3 Hospital
Xi'an, Shaanxi, China
Actively Recruiting
21
Xianyang Hospital, Yan'an University
Xianyang, Shaanxi, China, 712000
Actively Recruiting
22
The First People's Hospital of Xianyang
Xianyang, Shaanxi, China
Actively Recruiting
23
Yulin No.1 Hospital
Yulin, Shaanxi, China
Not Yet Recruiting
24
Yulin No.2 Hospital
Yulin, Shaanxi, China
Not Yet Recruiting
25
Qilu Hospital of Shangdong University
Jinan, Shandong, China
Not Yet Recruiting
26
The PLA 960 Hospital
Jinan, Shandong, China
Actively Recruiting
27
The Second Hospital of Shandong University
Jinan, Shandong, China
Actively Recruiting
28
Liaocheng People's Hospital
Liaocheng, Shandong, China, 252000
Actively Recruiting
29
People's Hospital of Xinjiang Uygur Autonomous Region
Ürümqi, Xinjiang, China, 830000
Actively Recruiting
30
The Second Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China, 830000
Actively Recruiting
Research Team
W
Wen Jiang, Ph.D
CONTACT
X
Xuan Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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