Gender Incongruence in Danish Youth (GenDa): An Observational Cohort Study of Children and Adolescents Referred to a National Gender Identity Service

What this Trial Is About

This observational study investigates the health care program for Danish children and adolescents with gender incongruence, established in January 2016. It aims to characterize psychosocial profiles, development history, and treatment paths, while evaluating biological and psychosocial outcomes. The study focuses on growth, bone health, body composition, metabolic and hormone levels, mental health conditions like autism and psychiatric diagnoses, as well as social factors such as family environment and education. Participants are referred to a national gender identity service that includes specialized clinics for sexology, child and adolescent mental health, and growth and reproduction. The study monitors biological parameters before and during hormonal treatments like gonadotropin-releasing hormone analogues and cross-sex hormones. A biobank is also being established for those receiving hormone treatments to support future research. During the study, participants undergo assessments of body mass index, puberty status, bone mineral content, body fat and lean mass, hormone levels, blood pressure, reproductive organ ultrasounds, sperm analysis, psychiatric conditions, functioning levels, and suicide risk. These measurements are tracked over eight years to improve understanding of treatment effects and psychosocial well-being. The study also collects demographic and cultural data to support comprehensive analysis of health outcomes and quality of life.

Optimizing Individual Health Care for Young People With Gender Incongruence