Actively Recruiting
Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study
Led by Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University · Updated on 2026-04-14
60
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of the proposed pilot is to test the feasibility, acceptability, and preliminary efficacy of a 16-week sequential, multiple assessment randomized trial (SMART), which includes virtual Tai Chi/Qi Gong or α- Lipoic acid (ALA) supplements as an initial treatment, and acupuncture as the additional treatment, that examines a stepped-care intervention to address CIPN.
CONDITIONS
Official Title
Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Moderate or greater numbness and tingling (≥ 2/4) reported in the last week
- At least three months since last neurotoxic chemotherapy treatment
- Prior chemotherapy with paclitaxel, docetaxel, cisplatin, oxaliplatin, nab-paclitaxel, or carboplatin for stage I-III gastrointestinal cancers
- Ability to read and speak English
You will not qualify if you...
- Life expectancy of 3 months or less
- Neuropathy caused by other conditions like diabetes
- Planning to start new duloxetine or other pain medications during the study
- Regular alcohol use as defined (≥7 drinks/week women, ≥14 drinks/week men) or alcohol use disorder
- Current use of oral calcium, iron, or magnesium supplements
- Having thyroid disorders such as hypo- or hyperthyroidism
- Diagnosed thiamine deficiency confirmed by a physician
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sidney Kimmel Cancer Center at Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
Research Team
K
Kuang-Yi Wen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
6
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