Actively Recruiting
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Led by Medical College of Wisconsin · Updated on 2026-05-01
53
Participants Needed
2
Research Sites
388 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy. A dose of 30 Gy in 10 fractions will be delivered using the PRDR technique.
CONDITIONS
Official Title
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at diagnosis of brain metastases
- Eastern Cooperative Oncology Group (ECOG) Performance Score less than 2
- Biopsy-proven solid malignancy with brain metastases confirmed by imaging or pathology
- Prior systemic therapy allowed
- Life expectancy greater than six months from extracranial disease
- Presence of measurable brain metastasis
- Prior brain metastasis treatments allowed if completed at least 7 days (stereotactic radiosurgery) or 14 days (surgical resection) before enrollment
- At least one week post-open biopsy if performed
- Creatinine clearance of 30 mL/min or higher
- Start PRDR WBRT within two weeks after registration
- Ability to complete neurocognitive function tests in English
- Previous or other controlled malignancies not affecting performance or life expectancy
- Willingness and ability to give consent and comply with study procedures
You will not qualify if you...
- Metastases from blood cancers or primary central nervous system malignancies
- Malignancy currently treated with curative intent
- Presence of leptomeningeal metastases
- Contraindications to MRI with contrast
- Contraindications to memantine or concurrent use of NMDA antagonists
- Stage IV-V chronic kidney disease or end-stage renal disease
- Tumor larger than 5 cm if not surgically removed
- Prior whole-brain radiation therapy
- History of dementia unrelated to brain metastases
- Women of childbearing potential who are pregnant or unwilling to use contraception during treatment
- Serious medical or psychiatric illnesses preventing consent or study completion
- Non-native English speakers due to potential impact on cognitive testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Froedtert Hospital & the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
2
Clement J. Zablocki Veterans Affairs Medical Center
Milwaukee, Wisconsin, United States, 53295
Actively Recruiting
Research Team
M
Medical College of Wisconsin Cancer Center Clinical Trials Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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