Actively Recruiting
Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
Led by CHU de Quebec-Universite Laval · Updated on 2025-07-29
100
Participants Needed
1
Research Sites
115 weeks
Total Duration
On this page
Sponsors
C
CHU de Quebec-Universite Laval
Lead Sponsor
C
Canadian Perioperative Anesthesia Clinical Trials (PACT) Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. The goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial to evaluate the impact of dexmedetomidine and lidocaine administered during major non-cardiac surgery on patient-centred outcomes.
CONDITIONS
Official Title
Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Scheduled for elective major non-cardiac surgery lasting 1.5 hours or longer with an expected hospital stay of at least one night
- Planned general anesthesia for surgery
- Able to complete baseline quality of recovery assessment
You will not qualify if you...
- Known contraindications to dexmedetomidine or lidocaine such as allergy to alpha-2 agonists or local anesthetics, severe kidney or liver failure, slow heart rate, or low blood pressure
- Regular use of alpha-2 agonists or local anesthetics before hospitalization
- Pregnant women
- Planned use of regional analgesia techniques like epidural or nerve blocks during surgery
- Planned postoperative intubation after recovery room discharge
- No fixed home address
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus)
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
Research Team
S
Sophie Guay, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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