Actively Recruiting
Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer
Led by Centre Hospitalier Universitaire Saint Pierre · Updated on 2025-05-30
20
Participants Needed
1
Research Sites
296 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This interventional, non-randomized, prospective trial aims to evaluate the role of endoscopic resection following neoadjuvant treatment in patients with locally advanced rectal cancer. Phase I focuses on assessing the feasibility, safety and efficacy of endoscopic resection of residual scar or superficial residual neoplastic tissue following neoadjuvant treatment. Phase II explores the potential of this approach to guide patient selection for total mesorectal excision and to serve as a definitive treatment option for those with limited residual disease.
CONDITIONS
Official Title
Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Signed informed consent
- Diagnosed with locally advanced rectal cancer showing complete or near-complete clinical response after neoadjuvant therapy without invasive disease (greater than T2) or locoregional invasion on MRI and without metastatic disease on CT scan
- Diagnosed with locally advanced rectal cancer showing incomplete response with superficial residual lesions, no invasive features on endoscopic evaluation, no invasive disease (greater than T2) or locoregional invasion on MRI and no metastatic disease on CT scan
- No previous medical history of rectal cancer or rectal surgery
You will not qualify if you...
- Previous medical history of rectal cancer
- Previous rectal surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU Saint Pierre
Brussels, Belgium, 1000
Actively Recruiting
Research Team
M
Mariana Figueiredo
CONTACT
A
Amélie Deleporte
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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