Actively Recruiting
Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement
Led by University of South Carolina · Updated on 2026-05-05
336
Participants Needed
1
Research Sites
236 weeks
Total Duration
On this page
Sponsors
U
University of South Carolina
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \[≥150 min/week of MVPA\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.
CONDITIONS
Official Title
Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Had a knee replacement (primary, staged bilateral, independent bilateral, or revision) at least 12 months ago
- Have a computer, tablet, or smartphone with active internet access
- Self-report less than 60 minutes per week of moderate-intensity physical activity
- Are English-speaking and able to read study materials and consent in English
- Willing to complete 4 remote assessments including physical activity monitoring
- Willing to be randomly assigned to receive zero to four supplemental intervention components
You will not qualify if you...
- Have any contraindications to physical activity (e.g., chest pain)
- Have scheduled surgery within the next 12 months (e.g., hip or knee replacement)
- Have a mobility-limiting condition unrelated to knee replacement
- Live outside of the continental U.S.
- Do not have a regular physician or orthopedic surgeon
- Currently participating in physical therapy for the knee
- Participating in a structured weight loss or physical activity program
- Unable to provide proof of knee replacement surgery
- Have a body mass index (BMI) over 40 kg/m2
- Score over 30 on the PROMIS cognitive function assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of South Carolina
Columbia, South Carolina, United States, 29208
Actively Recruiting
Research Team
J
Jakob Nelson, MS
CONTACT
C
Christine Pellegrini, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
16
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