Actively Recruiting
Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement
Led by University of South Carolina · Updated on 2026-05-05
336
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
U
University of South Carolina
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to find out which additional support methods added to an online exercise program help adults with knee replacement increase their physical activity the most at 6 and 12 months. The study also looks at changes in pain and physical function over time. It focuses on adults who have had knee replacement surgery and currently do little to no moderate-intensity exercise. All participants will join the Energize! Exercise Program, a 6-month automated online plan that gradually increases physical activity from 75 to 200 minutes weekly. They will watch video lessons weekly during the first 3 months and monthly in months 4 to 6, complete related activities, and report their exercise each week to get automated feedback. In addition, participants will be randomly assigned to receive zero to four extra support features, such as phone coaching, progress reports sent to their doctors, motivational videos from others with knee replacements, and personalized feedback from a coach. During the study, participants complete four remote assessments, including physical activity monitoring. Researchers will track physical activity minutes per week, the percentage meeting activity guidelines, pain levels, and physical function from baseline to 6 and 12 months. Progress reports will be sent to providers at 3 and 6 months. The study runs until July 2029, with participants involved in activities and monitoring over the 6-month program and assessments extending to 12 months.
CONDITIONS
Brief Title
Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Had a knee replacement (primary, staged, bilateral, or revision) at least 12 months ago
- Have a computer, tablet, or smartphone with active internet access
- Self-report engaging in less than 60 minutes per week of moderate-intensity physical activity
- Be English-speaking and able to read consent and study materials in English
- Be willing to complete 4 remote assessments including physical activity monitoring
- Be willing to be randomly assigned to receive 0-4 supplemental intervention components
You will not qualify if you...
- Have any contraindications to physical activity such as chest pain
- Have a scheduled surgery within the next 12 months (e.g., hip or knee replacement)
- Have a mobility-limiting condition unrelated to knee replacement
- Live outside of the continental U.S.
- Do not have a regular physician or orthopedic surgeon
- Are currently participating in physical therapy for the knee
- Are participating in a structured weight loss or physical activity program
- Unable to provide proof of knee replacement surgery
- Have a BMI greater than 40 kg/m2
- Score greater than 30 on PROMIS cognitive function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (remote)
Duration - 6 months
Participants follow a 6-month, fully automated online behavioral exercise program designed to increase moderate-intensity physical activity, including weekly to monthly video lessons and activities. Some participants may also receive supplemental components such as phone coaching calls, progress reports to providers, monthly videos from peers, and individualized feedback emails.
Weekly to monthly remote interactions depending on assigned intervention components
Duration - Up to 6 months after treatment (total 12 months)
Participants are monitored for physical activity, pain intensity, and physical function up to 12 months after starting the program to assess sustained benefits.
Remote assessments at 6 and 12 months
Trial Site Locations
Total: 1 location
1
University of South Carolina
Columbia, South Carolina, United States, 29208
Actively Recruiting
Research Team
J
Jakob Nelson, MS
C
Christine Pellegrini, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
16
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here