Actively Recruiting
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Led by Corxel Pharmaceuticals · Updated on 2026-03-13
740
Participants Needed
83
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin Scale score when compared with placebo following AIS. 2. Risk of symptomatic intracranial hemorrhage of JX10 in participants with AIS. During Part 1, participants will be randomized to JX 10 (1mg/kg, 3 mg/kg) or placebo. During Part 2, participants will receive JX10 (optimal dose chosen from Part 1) or placebo.
CONDITIONS
Official Title
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 90 years old
- Acute ischemic stroke with clinical symptoms and high-grade or complete occlusion in specific brain arteries (intracranial internal carotid, M1, M2, distal branches of middle cerebral artery, anterior cerebral artery, or posterior cerebral artery)
- Radiographic evidence showing salvageable brain tissue
- Pre-treatment NIH Stroke Scale score of 5 or higher
You will not qualify if you...
- Large core infarction or occlusion in more than one vascular territory seen on imaging before randomization
- Significant brain swelling or mass effect
- Evidence of acute intracranial or extracranial hemorrhage, brain tumor (except small meningioma), neoplasm, or arteriovenous malformation
- Clinical history or imaging suggesting chronic intracranial occlusion
- Active significant bleeding or conditions increasing major bleeding risk
- Severe uncontrolled hypertension (systolic ≥ 185 mmHg or diastolic ≥ 110 mmHg) not controlled by medication
- Known bleeding disorders or coagulopathy (platelet count < 100,000/µL, INR > 1.7, aPTT > 40 seconds, or prothrombin time > 15 seconds)
- Recent major trauma, surgery, or invasive procedures
- Pre-existing medical, neurological, or psychiatric diseases that may interfere with study assessments
- Blood glucose above 400 mg/dL or below 50 mg/dL before treatment unless corrected prior to study treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 83 locations
1
Corxel Investigational Site
Long Beach, California, United States, 90806
Actively Recruiting
2
Corxel Investigational Site
Sacramento, California, United States, 95817
Actively Recruiting
3
Corxel Investigational Site
Colorado Springs, Colorado, United States, 80909
Actively Recruiting
4
Corxel Investigational Site
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
5
Corxel Investigational Site
Delray Beach, Florida, United States, 33484
Actively Recruiting
6
Corxel Investigational Site
Chicago, Illinois, United States, 60616
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7
Corxel Investigational Site
Wichita, Kansas, United States, 67214
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8
Corxel Investigational Site
Baltimore, Maryland, United States, 21215
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9
Corxel Investigational Site
Kalamazoo, Michigan, United States, 49048
Actively Recruiting
10
Corxel Investigational Site
Traverse City, Michigan, United States, 49684
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11
Corxel Investigational Site
St Louis, Missouri, United States, 63110
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12
Corxel Investigational Site
Great Neck, New York, United States, 11021
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13
Corxel Investigational Site
New York, New York, United States, 10029
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14
Corxel Investigational Site
Toledo, Ohio, United States, 43606
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15
Corxel Investigational Site
Tulsa, Oklahoma, United States, 74104
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16
Corxel Investigational Site
Dallas, Texas, United States, 75246
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17
Corxel Investigational Site
Houston, Texas, United States, 77030
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18
Corxel Investigational Site
Ghent, Belgium, 9000
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19
Corxel Investigational Site
Blagoevgrad, Bulgaria
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20
Corxel Investigational Site
Burgas, Bulgaria
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21
Corxel Investigational Site
Pleven, Bulgaria
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22
Corxel Investigational Site
Plovdiv, Bulgaria
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23
Corxel Investigational Site
Sofia, Bulgaria, 1606
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24
Corxel Investigational Site
Edmonton, Canada
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25
Corxel Investigational Site
Kingston, Canada
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26
Corxel Investigational Site
Baotou, China
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27
Corxel Investigational Site
Beijing, China
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28
Corxel Investigational Site
Beijing, China
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29
Corxel Investigational Site
Changchun, China
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30
Corxel Investigational Site
Guangzhou, China
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31
Corxel Investigational Site,
Harbin, China
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32
Corxel Investigational Site
Harbin, China
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33
Corxel Investigational Site
Kaili, China
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34
Corxel Investigational Site
Linfen, China
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35
Corxel Investigational Site
Shanghai, China
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36
Corxel Investigational Site
Shenyang, China
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37
Corxel Investigational Site
Suzhou, China
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38
Corxel Investigational Site
Weifang, China
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39
Corxel Investigational Site
Xuzhou, China
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40
Corxel Investigational site
Lille, France
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41
Corxel Investigational site
Paris, France
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42
Corxel Investigational Site
Altenburg, Germany
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43
Corxel Investigational Site
Leipzig, Germany
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44
Corxel Investigational Site
Lübeck, Germany
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45
Corxel Investigational Site
Trier, Germany
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46
Corxel Investigational Site
Athens, Greece
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47
Corxel Investigational Site
Chaïdári, Greece
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48
Corxel Investigational Site
Pátrai, Greece
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49
Corxel Investigational Site
Thessaloniki, Greece
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50
Corxel Investigational Site
Pavia, Italy
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51
Corxel Investigational Site
Roma, Italy
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52
Corxel Investigational Site
Fukuoka, Japan
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53
Corxel Investigational Site
Hyōgo, Japan
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54
Corxel Investigational site
Ibaraki, Japan
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55
Corxel Investigational Site
Kamakura, Japan
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56
Corxel Investigational Site
Meguro City, Japan
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57
Corxel Investigational Site
Mitaka, Japan
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58
Corxel Investigational Site
Miyagi, Japan
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59
Corxel Investigational site
Toyota, Japan
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60
Corxel Investigational Site
Yamagata, Japan
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61
Corxel Investigational Site
Yamaguchi, Japan
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62
Corxel Investigational Site
Daugavpils, Latvia
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63
Corxel Investigational Site
Riga, Latvia
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64
Corxel Investigational Site
Kaunas, Lithuania
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65
Corxel Investigational Site
Vilnius, Lithuania
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66
Corxel Investigational Site
Kuching, Malaysia
Actively Recruiting
67
Corxel Investigational Site
Braga, Portugal
Actively Recruiting
68
Corxel Investigational Site
Loures, Portugal
Actively Recruiting
69
Corxel Investigational Site
Belgrade, Serbia
Actively Recruiting
70
Corxel Investigational Site
Kragujevac, Serbia
Actively Recruiting
71
Corxel Investigational Site
Niš, Serbia
Actively Recruiting
72
Corxel Investigational Site
Novi Sad, Serbia
Actively Recruiting
73
Corxel Investigational Site
Seoul, South Korea
Actively Recruiting
74
Corxel Investigational Site
A Coruña, Spain
Actively Recruiting
75
Corxel Investigational Site
Albacete, Spain
Actively Recruiting
76
Corxel Investigational Site
Barcelona, Spain
Actively Recruiting
77
Corxel Investigational Site
Girona, Spain
Actively Recruiting
78
Corxel Investigational Site
Madrid, Spain
Actively Recruiting
79
Corxel Investigational Site
Málaga, Spain
Actively Recruiting
80
Corxel Investigational Site
Seville, Spain
Actively Recruiting
81
Corxel Investigational Site
Valencia, Spain
Actively Recruiting
82
Corxel Investigational Site
Bangkok, Thailand
Actively Recruiting
83
Corxel Investigational Site
Khon Kaen, Thailand
Actively Recruiting
Research Team
C
Corxel Pharmaceuticals Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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