Actively Recruiting
Optimizing Treatment of Adhesive Small Bowel Obstruction
Led by University of California, Los Angeles · Updated on 2024-05-08
40
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team. The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO. This feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.
CONDITIONS
Official Title
Optimizing Treatment of Adhesive Small Bowel Obstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 18 years of age or older
- Diagnosis of adhesive small bowel obstruction confirmed by symptoms such as nausea, vomiting, abdominal pain, distended abdomen, or CT evidence
You will not qualify if you...
- Pregnant, breastfeeding, or unwilling to use birth control during the study
- Any condition or abnormality deemed by the investigator to compromise patient safety or data quality
- Unstable angina or recent myocardial infarction or stroke within 6 months
- Nonadhesive small bowel obstruction including paralytic ileus, incarcerated hernia, fecal impaction, intra-abdominal malignancy, or early adhesive SBO within 4 weeks of prior abdominal surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California, Los Angeles, David Geffen School of Medicine
Los Angeles, California, United States, 90024
Actively Recruiting
Research Team
S
Steven Stokes
CONTACT
E
Edward H Livingston, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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