Actively Recruiting
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
Led by University of Virginia · Updated on 2025-07-22
40
Participants Needed
1
Research Sites
54 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
CONDITIONS
Official Title
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged 25-50 years
- Signed and dated informed consent form
- Able to understand the study goals and procedures and willing to follow all study requirements
- Proficient in English to follow verbal commands during ultrasound
- In good general health based on medical history
- Normal blood count and adequate organ function as shown by lab results
- Agree to follow lifestyle considerations during the study
You will not qualify if you...
- Chronic medical conditions such as cancer, cerebrovascular disease, kidney disease, heart disease, lung disease, liver disease, hypertension, diabetes, HIV infection, immunodeficiencies, organ transplantation, tuberculosis, cystic fibrosis, autoimmune disorders, or anemia syndromes
- High blood pressure with systolic ≥160 mm Hg or diastolic ≥100 mm Hg, or requiring multiple medications
- Obesity with body mass index ≥30 kg/m2
- Use of anti-inflammatory, immunomodulatory, anticoagulant, or antiplatelet drugs within one week prior to ultrasound
- Pregnancy, breastfeeding, or planning pregnancy during study
- Active infections or fever within two weeks prior to ultrasound
- Allergies to ultrasound gel
- Participation in other investigational treatments within one month
- Recent vaccination within one month
- Current smoking or nicotine use within two weeks
- Recreational drug use within two weeks
- History of arrhythmia, deep vein thrombosis, pulmonary embolism, bleeding disorders, or seizures
- Prior vagotomy
- Presence of implantable medical devices like pacemakers or hearing aids
- Recent surgery or injury within three months
- Prior surgery on thyroid, parathyroid, esophagus, stomach, or spleen
- Investigator judgment deeming participant unsuitable for safety or study integrity reasons
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Virginia, Division of Nephrology; Center for Immunity, Inflammation & Regenerative Medicine
Charlottesville, Virginia, United States, 22903
Actively Recruiting
Research Team
M
Mark D. Okusa, MD, FASN
CONTACT
I
Igor A. Shumilin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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