Actively Recruiting
The Options 2 Study
Led by University of Wisconsin, Madison · Updated on 2025-09-04
300
Participants Needed
1
Research Sites
218 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate how well nicotine pouches and nicotine mini lozenges serve as substitutes for cigarettes when people try to switch from smoking to using these alternate nicotine products. Participants will: * Use nicotine pouches, nicotine mini lozenges, or no study product for a week and then try not to smoke for 3 weeks. * Have 6 in-person research visits and 1 follow-up call * Complete questionnaires at each study contact and use a smartphone app to record smoking and study product use
CONDITIONS
Official Title
The Options 2 Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years old or older (able to legally purchase tobacco products)
- Able to read and communicate in English
- No plans to quit smoking in the next 30 days
- Willing to stop using nicotine replacement or varenicline
- Willing to stop using bupropion if currently used for smoking cessation only
- Smoking at least 5 cigarettes per day for the past 6 months
- Exhaled carbon monoxide level of 6 ppm or higher
- No use of nicotine pouches or smokeless tobacco including snus within the last 6 months
You will not qualify if you...
- Currently in treatment for psychosis or bipolar disorder
- Currently taking bupropion for reasons other than smoking cessation
- Currently pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
M
Megan Piper, PhD
CONTACT
M
Mark Zehner
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here