Actively Recruiting
OR6A2 on Monocytes and Cardiovascular Outcomes in Myocardial Ischemia-Reperfusion Injury
Led by Southeast University, China · Updated on 2025-08-03
200
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study examines how the interaction between octanal (an OR6A2 receptor activator) and OR6A2 expression influences inflammation and clinical outcomes in Myocardial Ischemia-Reperfusion Injury patients. We analyze two key relationships: 1) The octanal-OR6A2 pathway's association with systemic oxidative stress/inflammatory biomarkers, and 2) How OR6A2 expression patterns on monocyte subtypes and plasma octanal levels correlate with major cardiovascular events. Patients undergoing this post-revascularization injury provided blood samples for OR6A2/octanal/inflammation measurements. IR Injury patients underwent 44-month clinical follow-up. Results may identify biological markers for personalized risk assessment after revascularization therapies. Ethics approval: Zhongda Hospital #2020ZDSYLL051-P01.
CONDITIONS
Official Title
OR6A2 on Monocytes and Cardiovascular Outcomes in Myocardial Ischemia-Reperfusion Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute myocardial infarction patients with coronary artery disease undergoing primary percutaneous coronary intervention and diagnosed with myocardial ischemia-reperfusion injury after PCI
- Age 18 to 90 years inclusive
You will not qualify if you...
- Active systemic infections
- Advanced heart failure (NYHA class III-IV)
- Acute cerebrovascular conditions
- Active myocarditis
- Cardiomyopathy
- Refractory ventricular tachycardia or fibrillation
- Diagnosis or treatment of malignancy within 5 years (except non-melanoma skin cancer or carcinoma in situ)
- Severe renal insufficiency (eGFR <30 mL/min/1.73m2 or dialysis dependence)
- Child-Pugh class C hepatic dysfunction
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Cardiology, Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
Research Team
W
Wenbin Lu, PhD
CONTACT
Y
Yahao Zhang, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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